Publications
Liu X, Sempere LF, Galimberti F, Freemantle SJ, Black C, Dragnev KH, Ma Y, Fiering S, Memoli V, Li H, DiRenzo J, Korc M, Cole CN, Bak M, Kauppinen S, Dmitrovsky E
Uncovering growth-suppressive MicroRNAs in lung cancer.
Clin Cancer Res 2009 Feb 15; 15(4):1177-83
PMID: 19228723 [PubMed - indexed for MEDLINE]
Estruch F, Peiro-Chova L, Gomez-Navarro N, Durban J, Hodge C, Del Olmo M, Cole CN
A genetic screen in Saccharomyces cerevisiae identifies new genes that interact with mex67-5, a temperature-sensitive allele of the gene encoding the mRNA export receptor.
Mol Genet Genomics 2009 Jan; 281(1):125-34
PMID: 19034519 [PubMed - indexed for MEDLINE]
Scarcelli JJ, Viggiano S, Hodge CA, Heath CV, Amberg DC, Cole CN
Synthetic genetic array analysis in Saccharomyces cerevisiae provides evidence for an interaction between RAT8/DBP5 and genes encoding P-body components.
Genetics 2008 Aug; 179(4):1945-55
PMID: 18689878 [PubMed - indexed for MEDLINE]
Wolyniak MJ, Cole CN
Harnessing genomics to explore the processes and evolution of mRNA export.
RNA Biol 2008 Apr-Jun; 5(2):68-72
PMID: 18483471 [PubMed - indexed for MEDLINE]
Sempere LF, Christensen M, Silahtaroglu A, Bak M, Heath CV, Schwartz G, Wells W, Kauppinen S, Cole CN
Altered MicroRNA expression confined to specific epithelial cell subpopulations in breast cancer.
Cancer Res 2007 Dec 15; 67(24):11612-20
PMID: 18089790 [PubMed - indexed for MEDLINE]
Scarcelli JJ, Hodge CA, Cole CN
The yeast integral membrane protein Apq12 potentially links membrane dynamics to assembly of nuclear pore complexes.
J Cell Biol 2007 Aug 27; 178(5):799-812
PMID: 17724120 [PubMed - indexed for MEDLINE]
Gross T, Siepmann A, Sturm D, Windgassen M, Scarcelli JJ, Seedorf M, Cole CN, Krebber H
The DEAD-box RNA helicase Dbp5 functions in translation termination.
Science 2007 Feb 2; 315(5812):646-9
PMID: 17272721 [PubMed - indexed for MEDLINE]
Rollenhagen C, Hodge CA, Cole CN
Following temperature stress, export of heat shock mRNA occurs efficiently in cells with mutations in genes normally important for mRNA export.
Eukaryot Cell 2007 Mar; 6(3):505-13
PMID: 17259545 [PubMed - indexed for MEDLINE]
Sempere LF, Cole CN, McPeek MA, Peterson KJ
The phylogenetic distribution of metazoan microRNAs: insights into evolutionary complexity and constraint.
J Exp Zool B Mol Dev Evol 2006 Nov 15; 306(6):575-88
PMID: 16838302 [PubMed - indexed for MEDLINE]
Cole CN, Scarcelli JJ
Unravelling mRNA export.
Nat Cell Biol 2006 Jul; 8(7):645-7
PMID: 16820771 [PubMed - indexed for MEDLINE]
Cole CN, Scarcelli JJ
Transport of messenger RNA from the nucleus to the cytoplasm.
Curr Opin Cell Biol 2006 Jun; 18(3):299-306
PMID: 16682182 [PubMed - indexed for MEDLINE]
Dunn EF, Hammell CM, Hodge CA, Cole CN
Yeast poly(A)-binding protein, Pab1, and PAN, a poly(A) nuclease complex recruited by Pab1, connect mRNA biogenesis to export.
Genes Dev 2005 Jan 1; 19(1):90-103
PMID: 15630021 [PubMed - indexed for MEDLINE]
Estruch F, Hodge CA, Rodriguez-Navarro S, Cole CN
Physical and genetic interactions link the yeast protein Zds1p with mRNA nuclear export.
J Biol Chem 2005 Mar 11; 280(10):9691-7
PMID: 15619606 [PubMed - indexed for MEDLINE]
Rollenhagen C, Hodge CA, Cole CN
The nuclear pore complex and the DEAD box protein Rat8p/Dbp5p have nonessential features which appear to facilitate mRNA export following heat shock.
Mol Cell Biol 2004 Jun; 24(11):4869-79
PMID: 15143180 [PubMed - indexed for MEDLINE]
Farago M, Nahari T, Hammel C, Cole CN, Choder M
Rpb4p, a subunit of RNA polymerase II, mediates mRNA export during stress.
Mol Biol Cell 2003 Jul; 14(7):2744-55
PMID: 12857861 [PubMed - indexed for MEDLINE]
Estruch F, Cole CN
An early function during transcription for the yeast mRNA export factor Dbp5p/Rat8p suggested by its genetic and physical interactions with transcription factor IIH components.
Mol Biol Cell 2003 Apr; 14(4):1664-76
PMID: 12686617 [PubMed - indexed for MEDLINE]
Harris A, Migliardi R, Rechtman E, Cole CN, Yee AB, Garzozi HJ
Comparative analysis of the effects of dorzolamide and latanoprost on ocular hemodynamics in normal tension glaucoma patients.
Eur J Ophthalmol 2003 Jan-Feb; 13(1):24-31
PMID: 12635671 [PubMed - indexed for MEDLINE]
Hammell CM, Gross S, Zenklusen D, Heath CV, Stutz F, Moore C, Cole CN
Coupling of termination, 3' processing, and mRNA export.
Mol Cell Biol 2002 Sep; 22(18):6441-57
PMID: 12192043 [PubMed - indexed for MEDLINE]
Cole CN, Heath CV, Hodge CA, Hammell CM, Amberg DC
Analysis of RNA export.
Methods Enzymol 2002; 351():568-87
PMID: 12073369 [PubMed - indexed for MEDLINE]
Cole CN
Choreographing mRNA biogenesis.
Nat Genet 2001 Sep; 29(1):6-7
PMID: 11528378 [PubMed - indexed for MEDLINE]
Cole CN
mRNA export: the long and winding road.
Nat Cell Biol 2000 Apr; 2(4):E55-8
PMID: 10783248 [PubMed - indexed for MEDLINE]
Hodge CA, Colot HV, Stafford P, Cole CN
Rat8p/Dbp5p is a shuttling transport factor that interacts with Rat7p/Nup159p and Gle1p and suppresses the mRNA export defect of xpo1-1 cells.
EMBO J 1999 Oct 15; 18(20):5778-88
PMID: 10523319 [PubMed - indexed for MEDLINE]
Belgareh N, Snay-Hodge C, Pasteau F, Dagher S, Cole CN, Doye V
Functional characterization of a Nup159p-containing nuclear pore subcomplex.
Mol Biol Cell 1998 Dec; 9(12):3475-92
PMID: 9843582 [PubMed - indexed for MEDLINE]
Cole CN, Hammell CM
Nucleocytoplasmic transport: driving and directing transport.
Curr Biol 1998 May 21; 8(11):R368-72
PMID: 9635180 [PubMed - indexed for MEDLINE]
Snay-Hodge CA, Colot HV, Goldstein AL, Cole CN
Dbp5p/Rat8p is a yeast nuclear pore-associated DEAD-box protein essential for RNA export.
EMBO J 1998 May 1; 17(9):2663-76
PMID: 9564048 [PubMed - indexed for MEDLINE]
Saavedra CA, Hammell CM, Heath CV, Cole CN
Yeast heat shock mRNAs are exported through a distinct pathway defined by Rip1p.
Genes Dev 1997 Nov 1; 11(21):2845-56
PMID: 9353254 [PubMed - indexed for MEDLINE]
Wang XS, Diener K, Manthey CL, Wang S, Rosenzweig B, Bray J, Delaney J, Cole CN, Chan-Hui PY, Mantlo N, Lichenstein HS, Zukowski M, Yao Z
Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase.
J Biol Chem 1997 Sep 19; 272(38):23668-74
PMID: 9295308 [PubMed - indexed for MEDLINE]
Conzen SD, Snay CA, Cole CN
Identification of a novel antiapoptotic functional domain in simian virus 40 large T antigen.
J Virol 1997 Jun; 71(6):4536-43
PMID: 9151847 [PubMed - indexed for MEDLINE]
Cole CN, Saavedra C
Regulation of the export of RNA from the nucleus.
Semin Cell Dev Biol 1997 Feb; 8(1):71-8
PMID: 15001108 [PubMed]
Dockendorff TC, Heath CV, Goldstein AL, Snay CA, Cole CN
C-terminal truncations of the yeast nucleoporin Nup145p produce a rapid temperature-conditional mRNA export defect and alterations to nuclear structure.
Mol Cell Biol 1997 Feb; 17(2):906-20
PMID: 9001245 [PubMed - indexed for MEDLINE]
Lu M, Conzen SD, Cole CN, Arrick BA
Characterization of functional messenger RNA splice variants of BRCA1 expressed in nonmalignant and tumor-derived breast cells.
Cancer Res 1996 Oct 15; 56(20):4578-81
PMID: 8840964 [PubMed - indexed for MEDLINE]
Del Priore V, Snay CA, Bahr A, Cole CN
The product of the Saccharomyces cerevisiae RSS1 gene, identified as a high-copy suppressor of the rat7-1 temperature-sensitive allele of the RAT7/NUP159 nucleoporin, is required for efficient mRNA export.
Mol Biol Cell 1996 Oct; 7(10):1601-21
PMID: 8898365 [PubMed - indexed for MEDLINE]
Anderson MM, Chen J, Cole CN, Conrad SE
Activation of the human thymidine kinase (TK) promoter by simian virus 40 large T antigen requires both the T antigen pRb family-binding domain and TK promoter sequences resembling E2F-binding sites.
J Virol 1996 Sep; 70(9):6304-13
PMID: 8709258 [PubMed - indexed for MEDLINE]
Saavedra C, Tung KS, Amberg DC, Hopper AK, Cole CN
Regulation of mRNA export in response to stress in Saccharomyces cerevisiae.
Genes Dev 1996 Jul 1; 10(13):1608-20
PMID: 8682292 [PubMed - indexed for MEDLINE]
Goldstein AL, Snay CA, Heath CV, Cole CN
Pleiotropic nuclear defects associated with a conditional allele of the novel nucleoporin Rat9p/Nup85p.
Mol Biol Cell 1996 Jun; 7(6):917-34
PMID: 8816998 [PubMed - indexed for MEDLINE]
Conzen SD, Cole CN
The three transforming regions of SV40 T antigen are required for immortalization of primary mouse embryo fibroblasts.
Oncogene 1995 Dec 7; 11(11):2295-302
PMID: 8570180 [PubMed - indexed for MEDLINE]
Heath CV, Copeland CS, Amberg DC, Del Priore V, Snyder M, Cole CN
Nuclear pore complex clustering and nuclear accumulation of poly(A)+ RNA associated with mutation of the Saccharomyces cerevisiae RAT2/NUP120 gene.
J Cell Biol 1995 Dec; 131(6 Pt 2):1677-97
PMID: 8557737 [PubMed - indexed for MEDLINE]
Del Sal G, Ruaro EM, Utrera R, Cole CN, Levine AJ, Schneider C
Gas1-induced growth suppression requires a transactivation-independent p53 function.
Mol Cell Biol 1995 Dec; 15(12):7152-60
PMID: 8524283 [PubMed - indexed for MEDLINE]
Casaz P, Rice PW, Cole CN, Hansen U
A TEF-1-independent mechanism for activation of the simian virus 40 (SV40) late promoter by mutant SV40 large T antigens.
J Virol 1995 Jun; 69(6):3501-9
PMID: 7745697 [PubMed - indexed for MEDLINE]
Gorsch LC, Dockendorff TC, Cole CN
A conditional allele of the novel repeat-containing yeast nucleoporin RAT7/NUP159 causes both rapid cessation of mRNA export and reversible clustering of nuclear pore complexes.
J Cell Biol 1995 May; 129(4):939-55
PMID: 7744966 [PubMed - indexed for MEDLINE]
Li O, Heath CV, Amberg DC, Dockendorff TC, Copeland CS, Snyder M, Cole CN
Mutation or deletion of the Saccharomyces cerevisiae RAT3/NUP133 gene causes temperature-dependent nuclear accumulation of poly(A)+ RNA and constitutive clustering of nuclear pore complexes.
Mol Biol Cell 1995 Apr; 6(4):401-417
PMID: 7626806 [PubMed - indexed for MEDLINE]
Rajan P, Swaminathan S, Zhu J, Cole CN, Barber G, Tevethia MJ, Thimmapaya B
A novel translational regulation function for the simian virus 40 large-T antigen gene.
J Virol 1995 Feb; 69(2):785-95
PMID: 7815544 [PubMed - indexed for MEDLINE]
Schlenstedt G, Saavedra C, Loeb JD, Cole CN, Silver PA
The GTP-bound form of the yeast Ran/TC4 homologue blocks nuclear protein import and appearance of poly(A)+ RNA in the cytoplasm.
Proc Natl Acad Sci U S A 1995 Jan 3; 92(1):225-9
PMID: 7816822 [PubMed - indexed for MEDLINE]
Quartin RS, Cole CN, Pipas JM, Levine AJ
The amino-terminal functions of the simian virus 40 large T antigen are required to overcome wild-type p53-mediated growth arrest of cells.
J Virol 1994 Mar; 68(3):1334-41
PMID: 8107198 [PubMed - indexed for MEDLINE]
Rice PW, Cole CN
Efficient transcriptional activation of many simple modular promoters by simian virus 40 large T antigen.
J Virol 1993 Nov; 67(11):6689-97
PMID: 8411371 [PubMed - indexed for MEDLINE]
Amberg DC, Fleischmann M, Stagljar I, Cole CN, Aebi M
Nuclear PRP20 protein is required for mRNA export.
EMBO J 1993 Jan; 12(1):233-41
PMID: 7679070 [PubMed - indexed for MEDLINE]
Heath CV, Fanning E, Cole CN
Adenovirus helper function activity of simian virus 40 T antigen mutants.
Virology 1992 Aug; 189(2):762-5
PMID: 1641988 [PubMed - indexed for MEDLINE]
Amberg DC, Goldstein AL, Cole CN
Isolation and characterization of RAT1: an essential gene of Saccharomyces cerevisiae required for the efficient nucleocytoplasmic trafficking of mRNA.
Genes Dev 1992 Jul; 6(7):1173-89
PMID: 1628825 [PubMed - indexed for MEDLINE]
Bentivoglio CM, Zhu J, Cole CN
Mechanisms of interference with simian virus 40 (SV40) DNA replication by trans-dominant mutants of SV40 large T antigen.
J Virol 1992 Jul; 66(7):4209-19
PMID: 1318402 [PubMed - indexed for MEDLINE]
Zhu J, Rice PW, Gorsch L, Abate M, Cole CN
Transformation of a continuous rat embryo fibroblast cell line requires three separate domains of simian virus 40 large T antigen.
J Virol 1992 May; 66(5):2780-91
PMID: 1313902 [PubMed - indexed for MEDLINE]
Zhu JY, Abate M, Rice PW, Cole CN
The ability of simian virus 40 large T antigen to immortalize primary mouse embryo fibroblasts cosegregates with its ability to bind to p53.
J Virol 1991 Dec; 65(12):6872-80
PMID: 1658380 [PubMed - indexed for MEDLINE]
Zhu JY, Rice PW, Chamberlain M, Cole CN
Mapping the transcriptional transactivation function of simian virus 40 large T antigen.
J Virol 1991 Jun; 65(6):2778-90
PMID: 1851853 [PubMed - indexed for MEDLINE]
Stacy TP, Chamberlain M, Carswell S, Cole CN
The growth of simian virus 40 (SV40) host range/adenovirus helper function mutants in an African green monkey cell line that constitutively expresses the SV40 agnoprotein.
J Virol 1990 Jul; 64(7):3522-6
PMID: 2161954 [PubMed - indexed for MEDLINE]
Heath CV, Denome RM, Cole CN
Spatial constraints on polyadenylation signal function.
J Biol Chem 1990 Jun 5; 265(16):9098-104
PMID: 2160955 [PubMed - indexed for MEDLINE]
Stacy T, Chamberlain M, Cole CN
Simian virus 40 host range/helper function mutations cause multiple defects in viral late gene expression.
J Virol 1989 Dec; 63(12):5208-15
PMID: 2555552 [PubMed - indexed for MEDLINE]
Zhu JY, Cole CN
Linker insertion mutants of simian virus 40 large T antigen that show trans-dominant interference with wild-type large T antigen map to multiple sites within the T-antigen gene.
J Virol 1989 Nov; 63(11):4777-86
PMID: 2552152 [PubMed - indexed for MEDLINE]
Denome RM, Cole CN
Patterns of polyadenylation site selection in gene constructs containing multiple polyadenylation signals.
Mol Cell Biol 1988 Nov; 8(11):4829-39
PMID: 2463466 [PubMed - indexed for MEDLINE]
Cole CN, Stacy TP
Biological properties of simian virus 40 host range mutants lacking the COOH-terminus of large T antigen.
Virology 1987 Nov; 161(1):170-80
PMID: 2823459 [PubMed - indexed for MEDLINE]
Zhang F, Cole CN
Identification of a complex associated with processing and polyadenylation in vitro of herpes simplex virus type 1 thymidine kinase precursor RNA.
Mol Cell Biol 1987 Sep; 7(9):3277-86
PMID: 2823124 [PubMed - indexed for MEDLINE]
Zhang F, Denome RM, Cole CN
Fine-structure analysis of the processing and polyadenylation region of the herpes simplex virus type 1 thymidine kinase gene by using linker scanning, internal deletion, and insertion mutations.
Mol Cell Biol 1986 Dec; 6(12):4611-23
PMID: 2879221 [PubMed - indexed for MEDLINE]
Jarvis DL, Cole CN, Butel JS
Absence of a structural basis for intracellular recognition and differential localization of nuclear and plasma membrane-associated forms of simian virus 40 large tumor antigen.
Mol Cell Biol 1986 Mar; 6(3):758-67
PMID: 3022127 [PubMed - indexed for MEDLINE]
Cole CN, Tornow J, Clark R, Tjian R
Properties of the simian virus 40 (SV40) large T antigens encoded by SV40 mutants with deletions in gene A.
J Virol 1986 Feb; 57(2):539-46
PMID: 3003386 [PubMed - indexed for MEDLINE]
Cole CN, Stacy TP
Identification of sequences in the herpes simplex virus thymidine kinase gene required for efficient processing and polyadenylation.
Mol Cell Biol 1985 Aug; 5(8):2104-13
PMID: 3018551 [PubMed - indexed for MEDLINE]
Tornow J, Polvino-Bodnar M, Santangelo G, Cole CN
Two separable functional domains of simian virus 40 large T antigen: carboxyl-terminal region of simian virus 40 large T antigen is required for efficient capsid protein synthesis.
J Virol 1985 Feb; 53(2):415-24
PMID: 2982029 [PubMed - indexed for MEDLINE]
Tornow J, Cole CN
Intracistronic complementation in the simian virus 40 A gene.
Proc Natl Acad Sci U S A 1983 Oct; 80(20):6312-6
PMID: 6312452 [PubMed - indexed for MEDLINE]
Tornow J, Cole CN
Nonviable mutants of simian virus 40 with deletions near the 3' end of gene A define a function for large T antigen required after onset of viral DNA replication.
J Virol 1983 Sep; 47(3):487-94
PMID: 6312080 [PubMed - indexed for MEDLINE]
Santangelo GM, Cole CN
Preparation of a "functional library" of African green monkey DNA fragments which substitute for the processing/polyadenylation signal in the herpes simplex virus type 1 thymidine kinase gene.
Mol Cell Biol 1983 Apr; 3(4):643-53
PMID: 6304500 [PubMed - indexed for MEDLINE]
Cole CN, Santangelo GM
Analysis in Cos-1 cells of processing and polyadenylation signals by using derivatives of the herpes simplex virus type 1 thymidine kinase gene.
Mol Cell Biol 1983 Feb; 3(2):267-79
PMID: 6300661 [PubMed - indexed for MEDLINE]
Polvino-Bodnar M, Cole CN
Construction and characterization of viable deletion mutants of simian virus 40 lacking sequences near the 3' end of the early region.
J Virol 1982 Aug; 43(2):489-502
PMID: 6287029 [PubMed - indexed for MEDLINE]
Cole CN, Crawford LV, Berg P
Simian virus 40 mutants with deletions at the 3' end of the early region are defective in adenovirus helper function.
J Virol 1979 Jun; 30(3):683-91
PMID: 225537 [PubMed - indexed for MEDLINE]
Crawford LV, Cole CN, Smith AE, Paucha E, Tegtmeyer P, Rundell K, Berg P
Organization and expression of early genes of simian virus 40.
Proc Natl Acad Sci U S A 1978 Jan; 75(1):117-21
PMID: 203926 [PubMed - indexed for MEDLINE]
Cole CN, Landers T, Goff SP, Manteuil-Brutlag S, Berg P
Physical and genetic characterization of deletion mutants of simian virus 40 constructed in vitro.
J Virol 1977 Oct; 24(1):277-94
PMID: 198579 [PubMed - indexed for MEDLINE]
Davis MA, Kaplan ML, Ahnberg DS, Cole CN
A modified Tc-99m-phytate colloid for liver-spleen imaging.
Int J Appl Radiat Isot 1977 Jan-Feb; 28(1-2):123-30
PMID: 404259 [PubMed - indexed for MEDLINE]
Cole CN
An efficient radiopharmaceutical record-keeping system.
Hosp Formul 1976 Jul; 11(7):385, 388-9
PMID: 1026697 [PubMed - indexed for MEDLINE]
Cole CN
Defective interfering (di) particles of poliovirus.
Prog Med Virol 1975; 20():180-207
PMID: 172972 [PubMed - indexed for MEDLINE]
Cole CN, Baltimore D
Defective interfering particles of poliovirus. IV. Mechanisms of enrichment.
J Virol 1973 Dec; 12(6):1414-26
PMID: 4357514 [PubMed - indexed for MEDLINE]
Cole CN, Baltimore D
Defective interfering particles of poliovirus. 3. Interference and enrichment.
J Mol Biol 1973 May 25; 76(3):345-61
PMID: 4354478 [PubMed - indexed for MEDLINE]
Cole CN, Baltimore D
Defective interfering particles of poliovirus. II. Nature of the defect.
J Mol Biol 1973 May 25; 76(3):325-43
PMID: 4354477 [PubMed - indexed for MEDLINE]
Cole CN, Smoler D, Wimmer E, Baltimore D
Defective interfering particles of poliovirus. I. Isolation and physical properties.
J Virol 1971 Apr; 7(4):478-85
PMID: 4329564 [PubMed - indexed for MEDLINE]