Biomedical Physiology

Donald Bartlett, Jr., M.D.

Andrew C. Vail Professor of Physiology
Research Description: Mechanisms of control and integration of breathing movements by muscles of the respiratory pump and those of the upper airway. A possible role of heat stress in the Sudden Infant Death Syndrome.

Robert A. Darnall, M.D.

Professor of Pediatrics and Physiology
Research Description: The role of medullary serotonergic neurons in the Sudden Infant Death Syndrome. Inhibition of serotonergic neurons in the nucleus paragigantocellularis lateralis fragments sleep and decreases REM.

J. Andrew Daubenspeck, Ph.D.

Professor of Physiology, Adjunct Professor of Biomedical Engineering
Research Description: Cardiorespiratory control using heart rate variability and baroreflex characteristics to evaluate neonatal development and risk factors for sudden infant death.

Richard I. Enelow, M.D.

Professor of Medicine and Microbiology/Immunology
Vice-Chair for Research
Chief, Pulmonary/Critical Care
Research Description: T cell responses to influenza and other virus infection, and the mechanisms of immunopathology in respiratory virus infection.

Géza Fejes-Tóth, D.M.D.

Professor of Physiology
Research Description: Molecular biology of membrane transporters, cell biology and development of specific renal cell types; mechanism of action of steroid hormones.

Valerie Anne Galton, Ph.D.

Professor of Physiology
Research Description: The roles of the iodothyronine deiodinases in the regulation of intracellular thyroid hormone levels and thyroid hormone action during development and in adult mammals. Studies use mice made deficient in the either or both the types 1 and 2 iodothyronine deiodinase.

William R. Green, Ph.D.

Professor and Chair, Department of Microbiology and Immunology
Research Description: T cell immune responses to viral diseases; cell-mediated immunity to mouse retroviruses that cause either leukemia or immunodeficiency; immunity to the mouse acquired immunodeficiency syndrome (MAIDS) retroviral isolate and the mechanism of retroviral pathogenesis; studies on novel vaccine approaches.

Allan T. Gulledge, Ph.D.

Assistant Professor of Physiology
Research Description: Our focus is the cellular neurophysiology of the cerebral cortex, with emphasis on understanding signal integration and transmission within individual neurons.

Paul M. Guyre, Ph.D.

Professor of Physiology and of Microbiology & Immunology
Research Description: Mechanisms of hormone/cytokine interactions in control of immunity, Inflammation, sepsis, and autoimmunity.

Leslie P. Henderson, Ph.D.

Professor of Physiology and of Biochemistry
Research Description: The long-term goals of the laboratory are to understand how steroids alter the expression and function of ion channels involved in synaptic signaling, with specific emphasis on the actions of anabolic androgenic steroids.

Alexandra L. Howell, Ph.D.

Research Associate Professor of Medicine and of Microbiology and Immunology
Research Description: My laboratory studies cellular mechanisms that control HIV-1 infection and replication in the female reproductive tract, the role of steroid sex hormones in this process, and the potential of RNA interference to inhibit mucosal HIV-1 transmission.

John A. Kelly, M.B., M.D.

Assistant Professor of Medicine and of Microbiology & Immunology
Research Description: Using a Stat5 transgenic model of lymphoma we are examining the role of Stat5 in T-cell development, as well as the factors mediating Stat5-mediated lymphoma. This should help us elucidate the pathogenesis of lymphoma and identify targets for novel molecular therapies that will be then tested in our lymphoma model.

Timothy Lahey, M.D.

Assistant Professor of Medicine and of Microbiology and Immunology
Research Description: We study the means of modulating T cell immune responses during HIV infection, and also the immunology of mucosal transmission of HIV. We also analyze immune responses to TB in HIV-infected adults in Tanzania, and their relation to protection from TB disease.

James C. Leiter, M.D.

Professor of Physiology and Medicine
Research Description: Respiratory neurobiology especially in the areas of pH regulation in neurons and astrocytes, central chemosensitivity and comparative aspects of rhythm generation.

Robert A. Maue, Ph.D.

Professor of Physiology and of Biochemistry
Research Description: Cellular and molecular mechanisms underlying neuronal development in the CNS, particularly as related to neurodegenerative diseases; neurotrophin and growth factor actions; regulation of neuronal ion channels and genes; molecular biology; electrophysiology.

Anikó Náray-Fejes-Tóth, M.D.

Professor of Physiology
Research Description: Cellular and molecular biology of steroid hormone action in epithelial cells. In vivo studies using knockout and transgenic mice.

Eugene E. Nattie, M.D.

Professor of Physiology
Research Description: Central chemoreceptors that sense changes in brain pH and stimulate breathing. The role of central chemoreception in the medullary raphe in the sudden infant death syndrome.

William G. North, Ph.D.

Professor of Physiology
Research Description: Neuropeptides in breast cancer, in small-cell carcinoma, and in Alzheimer's disease.

William F.C. Rigby, M.D.

Professor of Medicine, Microbiology and Immunology
Research Description: Posttranscriptional regulation of cytokine and CD40 ligand gene expression, RNA-protein infections, Von Hippel-Lindau regulation of mRNA stability.

R. Brooks Robey, M.D., F.A.S.N.

Associate Professor of Medicine and of Physiology
Associate Chief of Staff for Research and Development (VA)
Research Description: Regulation and function of mammalian hexokinases with specific emphasis on the interface between metabolism and cell survival in both adaptive (ischemic preconditioning) and maladaptive (cancer) contexts.

Donald L. St. Germain, M.D.

Professor of Medicine and of Physiology
Research Description: To develop new strategies for the treatment of mental illness, developmental disorders and obesity by gaining greater insights into the biochemical and physiological consequences of alterations in thyroid hormone metabolism and action.

Bruce A. Stanton, Ph.D.

Professor of Physiology, Director of the Lung Biology Program, Director of the Superfund Basic Research Program, Director of the Cystic Fibrosis Research Development Program, Director of the Epithelial Biology Training Program.
Research Description: Ion channel regulation in kidney and lung, Cystic Fibrosis, molecular pathogenesis of Pseudomonas infection, and gene environment interactions.

Harold M. Swartz, M.D., Ph.D.

Professor of Radiology, Physiology and Community and Family Medicine, DMS
Adjunct Professor of Chemistry, Dartmouth College
Adjunct Professor of Engineering, Thayer School of Engineering
Research Description: The development and application of Electron Paramagnetic Resonance (EPR) to viable systems, including human subjects and animal models, especially 1. oximetry for cancer and peripheral vascular disease. 2. techniques for after-the-fact dosimetry to meet the need for rapid and accurate triage in a population that has potentially been exposed to doses that could cause the acute radiation syndrome (ARS).

Charles R. Wira, Ph.D.

Professor of Physiology
Research Description: Physiology of reproduction; cellular and molecular actions of sex hormones regulation of the mucosal immune system in the rodent and human female reproductive tract as it relates to protection against sexually transmitted diseases including HIV-1.

Hermes H. Yeh, Ph.D.

Professor and Chair of Physiology
Research Description: Cellular and molecular mechanisms of neuroreceptor interactions and plasticity in the adult and developing CNS.