PEMM Participating Faculty: A - L
Angeline S. Andrew, Ph.D.
Research Assistant Professor, Community and Family Medicine
Research Description: Molecular diagnostics for bladder and lung cancers, toxic metal carcinogenesis, genetic susceptibility, gene-environment interactions.
Donald Bartlett, Jr., M.D.
Andrew C. Vail Professor of Physiology
Research Description: Mechanisms of control and integration of breathing movements by muscles of the respiratory pump and those of the upper airway. A possible role of heat stress in the Sudden Infant Death Syndrome.
Paul J Beisswenger, M.D.
Professor of Medicine
Section of Endocrinology, Diabetes, and Metabolism
Research Description: Control of non-enzymatic glycation and oxidative stress, and their role in suceptibility to diabetic complications. The research combines studies of human populations with powerful analytic laboratory techniques to address some of the important outstanding questions regarding diabetic complications.
David J. Bucci, Ph.D.
Assistant Professor of Psychological and Brain Sciences
Research Description: Behavioral and neurobiological factors that modulate learning and memory. Of particular interest are the neural mechanisms that are at the interface between attention and learning. We combine classical conditioning procedures with biochemical, pharmacological, and neuroanatomical techniques to study the role of cortical structures and subcortical neurochemical systems in these processes.
Michael Cole, Ph.D.
Professor of Pharmacology and Toxicology and Genetics, Norris Cotton Cancer Center Member
Research Description: Molecular basis of cancer; with emphasis on the role of transcription factors and chromatin modification on tumor cell growth with major emphasis on the Myc oncogen family and its role in the growth of both cancer and normal cells.
Ruth W. Craig, Ph.D.
Professor of Pharmacology and Toxicology
Research Description: Understanding how a key regulator of cell viability discovered in the laboratory, MCL1, contributes to tumorigenesis and can be targeted for cancer therapy.
Robert A. Darnall, M.D.
Professor of Pediatrics and Physiology
Research Description: The role of medullary serotonergic neurons in the Sudden Infant Death Syndrome. Inhibition of serotonergic neurons in the nucleus paragigantocellularis lateralis fragments sleep and decreases REM.
J. Andrew Daubenspeck, Ph.D.
Professor of Physiology, Adjunct Professor of Biomedical Engineering
Research Description: Cardiorespiratory control using heart rate variability and baroreflex characteristics to evaluate neonatal development and risk factors for sudden infant death.
Joyce A. DeLeo, Ph.D.
Professor of Anesthesiology and Irene Heinz Given Professor and Chair of Pharmacology and Toxicology, Director of the Neuroscience Center at Dartmouth
Research Description: Neuropharmacology; Neuroimmunology: Mechanisms that lead to chronic pain with a focus on spinal neuroimmune responses. Central neuroimmune activation and neuroinflammation play a key role in generating chronic pain. Utilization of molecular, cellular, and in vivo behavioral pharmacological approaches with the ultimate goal to develop novel, non-addictive therapeutics for the prevention and treatment of chronic neuropathic and low back pain.
James DiRenzo, Ph.D.
Associate Professor of Pharmacology and Toxicology
Research Description: Regulation of proliferation, self-renewal and cellular differentiation in mammary epithelial stem cells. Mammary gland carcinogenesis, tumor stem cell theory, genetic control over stem cell renewal.
Ethan Dmitrovsky, M.D.
Andrew G. Wallace Professor of Pharmacology and Toxicology, American Cancer Society Clinical Research Professor
Research Description: Translational research (bench to bedside) and studies of vitamin A derivatives known as retinoids and their roles in tumor cell differentiation therapy and chemoprevention.
Ann-Christine Duhaime, M.D.
Professor of Surgery (Pediatrics), Program Director: Pediatric Neurosurgery
Research Description: Brain injury in immaturity and epilepsy mechanisms. Traumatic brain injury in infants and children, age-related differences in brain recovery following head trauma, utilizing laboratory and biomechanical models to study mechanisms of recovery and to discover novel therapeutics to prevent the sequelae of head trauma.
Alan R. Eastman, Ph.D.
Professor of Pharmacology and Toxicology; Director, Molecular Therapeutics Program, NCCC;
Director, PEMM
Research Description: Cancer chemotherapy. Mechanisms of drug action: unbiased screen for novel drug targets and identification of selective anticancer drugs. Novel drug combinations: modulation of cell cycle arrest induced by DNA damaging agents; modulation of Bcl-2 proteins to enhance apoptosis.
Richard I. Enelow, M.D.
Professor of Medicine and Microbiology/Immunology
Vice-Chair for Research
Chief, Pulmonary/Critical Care
Research Description: T cell responses to influenza and other virus infection, and the mechanisms of immunopathology in respiratory virus infection.
Géza Fejes-Tóth, D.M.D.
Professor of Physiology
Research Description: Molecular biology of membrane transporters, cell biology and development of specific renal cell types; mechanism of action of steroid hormones.
Valerie Anne Galton, Ph.D.
Professor of Physiology
Research Description: The roles of the iodothyronine deiodinases in the regulation of intracellular thyroid hormone levels and thyroid hormone action during development and in adult mammals. Studies use mice made deficient in the either or both the types 1 and 2 iodothyronine deiodinase.
Rick Granger, Ph.D.
Professor of Psychological & Brain Sciences; Director
Research Description: We study computational and cognitive neuroscience: analyses of how our brains operate to perceive, comprehend and manipulate their environments, as well as how they fail in certain conditions. We strive both to understand and analyze brain circuits, and, where possible, to construct equivalent circuits -- ranging from fMRI neuroimaging studies to robotics. Throughout these studies, real-world applications are developed as our understanding deepens.
Alan I. Green, M.D.
Raymond Sobel Professor of Psychiatry, Professor of Pharmacology and Toxicology, Chair, Department of Psychiatry
Research Description: Animal and human studies of the actions of antipsychotic drugs, as related to their use in patients with schizophrenia and substance use disorders. The work focuses on brain reward circuitry, and manipulation of this circuitry by antipsychotic drugs and other psychoactive agents.
William R. Green, Ph.D.
Professor and Chair, Department of Microbiology and Immunology
Research Description: T cell immune responses to viral diseases; cell-mediated immunity to mouse retroviruses that cause either leukemia or immunodeficiency; immunity to the mouse acquired immunodeficiency syndrome (MAIDS) retroviral isolate and the mechanism of retroviral pathogenesis; studies on novel vaccine approaches.
Allan T. Gulledge, Ph.D.
Assistant Professor of Physiology
Research Description: Our focus is the cellular neurophysiology of the cerebral cortex, with emphasis on understanding signal integration and transmission within individual neurons.
Paul M. Guyre, Ph.D.
Professor of Physiology and of Microbiology & Immunology
Research Description: Mechanisms of hormone/cytokine interactions in control of immunity, Inflammation, sepsis, and autoimmunity.
Brent T. Harris, M.D., Ph.D.
Assistant Professor of Pathology
Research Description: Neurodegenerative diseases - ALS, Parkinson's, Prion diseases; CNS development and glial-neuronal cell biology; Molecular neurooncology. To understand the signaling mechanisms and molecules that normally promote upper and lower motor neuron survival and how these processes go awry in motor neuron diseases by utilizing cell culture methods and transgenic animal models which display similar clinical symptoms and histopathology to that found in human motor neuron disease. We are also studying genetic polymorphisms and the epidemiology of ALS and performing clinical trials to treat this disease.
Leslie P. Henderson, Ph.D.
Professor of Physiology and of Biochemistry
Research Description: The long-term goals of the laboratory are to understand how steroids alter the expression and function of ion channels involved in synaptic signaling, with specific emphasis on the actions of anabolic androgenic steroids.
William F. Hickey, M.D.
The John LaPorte Given Professor, Professor of Pathology, Senior Associate Dean of Academic Affairs
Research Description: Neuropathology, neuroimmunology, autoimmunity and inflammatory diseases of the CNS. Research focuses on problems related to the mechanisms of inflammation in the CNS. Laboratory techniques span the spectrum from molecular cloning to animal models of autoimmunity.
Gregory L. Holmes, M.D.
Professor of Medicine, Chief, Section of Neurology
Research Description: Effects of seizures on the developing brain. The laboratory focuses on the cognitive and electrophysiological consequences of recurrent seizures and status epilepticus.
Alexandra L. Howell, Ph.D.
Research Associate Professor of Medicine and of Microbiology and Immunology
Research Description: My laboratory studies cellular mechanisms that control HIV-1 infection and replication in the female reproductive tract, the role of steroid sex hormones in this process, and the potential of RNA interference to inhibit mucosal HIV-1 transmission.
Risto A. Kauppinen M.D., Ph.D.
Director, Bio-NMR Facility
Professor of Radiology
Research Description: We are developing magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) techniques for neuroscience applications. MR techniques under development have wide range of applications, including brain activation studies as well as imaging of acute brain injury and tumor pathology.
William Kelley, Ph.D.
Associate Professor of Psychological and Brain Sciences
Research Description: My research uses functional magnetic resonance imaging (fMRI) to gain a better understanding of human memory formation. Specifically, my work focuses on how different kinds of information like words (verbal) or unfamiliar faces (non-verbal) are encoded into long-term memory. A related focus of my work is to use imaging techniques to explore how memory formation may become compromised as a result of damage to certain brain regions.
John A. Kelly, M.B., M.D.
Assistant Professor of Medicine and of Microbiology & Immunology
Research Description: Using a Stat5 transgenic model of lymphoma we are examining the role of Stat5 in T-cell development, as well as the factors mediating Stat5-mediated lymphoma. This should help us elucidate the pathogenesis of lymphoma and identify targets for novel molecular therapies that will be then tested in our lymphoma model.
William B. Kinlaw, M. D.
Associate Professor of Medicine (Endocrinology and Metabolism)
Research Description: We employ cell culture and genetically engineered mouse models to understand the metabolic peculiarities of breast tumors, and to explore their potential as therapeutic targets.
Alexei F. Kisselev, Ph.D.
Assistant Professor of Pharmacology and Toxicology, Norris Cotton Cancer Center
Research Description: Mechanisms of selective killing of malignant cells by proteasome inhibitors; development and therapeutic application of specific inhibitors of proteasome different active sites; potential new targets in the ubiquitin-proteasome pathway.
Murray Korc, M.D.
Joseph M. Huber Professor of Medicine, Chairman Department of Medicine, and Professor of Pharmacology and Toxicology
Research Description: Mechanisms of action of growth factors, and the role of growth factors and their receptors in carcinogenesis, especially as it relates to enhanced mitogenic signaling, enhanced angiogenesis, and attenuated growth suppressive effects in pancreatic cancer.
Timothy Lahey, M.D.
Assistant Professor of Medicine and of Microbiology and Immunology
Research Description: We study the means of modulating T cell immune responses during HIV infection, and also the immunology of mucosal transmission of HIV. We also analyze immune responses to TB in HIV-infected adults in Tanzania, and their relation to protection from TB disease.
Stephen Lee, M.D., Ph.D.
Assistant Professor of Medicine (Neurology)
Research Description: Molecular pathogenesis of Parkinson's disease; The laboratory studies the biological function of Parkinson's disease-associated genes using genetic, molecular, cellular, and model organism approaches.
James C. Leiter, M.D.
Professor of Physiology and Medicine
Research Description: Respiratory neurobiology especially in the areas of pH regulation in neurons and astrocytes, central chemosensitivity and comparative aspects of rhythm generation.
Lionel D. Lewis, M.D.
Professor of Medicine and of Pharmacology and Toxicology
Research Description: The study of novel antineoplastic agents and their pharmacokinetics and pharmacodynamics when first given to cancer patients (i.e. first time in man, Phase I studies of new drugs in cancer patients); mechanisms of toxicity of nucleoside analogues and antineoplastic agents to the mitochondrion and ways of ameliorating this toxicity.
Christopher H. Lowrey, M.D.
Associate Professor of Medicine (Hematology/Oncology) and of Pharmacology and Toxicology
Research Description: Role of epigenetics and cell stress signaling in normal and disease-related blood cell production; development of novel pharmacologic therapies for sickle cell disease, thalassemia and leukemia.