Experimental Therapeutics 131
Offered Winter '09,'11
Course Directors
Michael Spinella Ph.D.
Jim DiRenzo Ph.D.
This course will present a survey of current methods and approaches in pharmacologic, molecular and experimental therapeutic research. Topics will include pharmacogenomics, pharmacogenetics, functional genomics, global gene expression, proteomics, gene targeting and drug development. The class will be lecture format. The class will meet for 3 hours each week.
| Lecture | Topic |
| 1 | Global Gene Expression/Array |
| 2 | Genomic Databases and Sequence Comparisons |
| 3 | RNAi/AS/Ribozymes |
| 4 | Experimental Mouse Genetics |
| 5 | Protein Purification/Chromatography |
| 6 | Proteomics/Mass Spectroscopy |
| 7 | Data Mining and Analysis |
| 8 | Exam I |
| 9 | Selected Topics Genomics/Proteomics |
| 10 | EPR |
| 11 | Pharmacologic Applications of PET |
| 12 | Open Date - no class |
| 13 | Fluorescence and Imaging |
| 14 | Fluorescence and Flow Cytometry |
| 15 | FRET/FRAP |
| 16 | Exam II |
| 17 | Enzymatic Assay Development |
| 18 | Pharmacogenetics I |
| 19 | Chemical Libraries: Design and Applications |
| 20 | Pharmacogenetics II |
| 21 | Drug discovery/Industrial Perspective |
| 22 | Molecular Epidemiology |
| 23 | Exam III |