Albert J. Erives
Assistant Professor of Biological Sciences
Research Areas: Developmental Biology, Evolutionary Biology, Genetics, Regulation of Gene Expression
Gene Regulation in Animal Evolution and Development
Our laboratory studies gene regulation in evolution and development. We use transgenic model systems such as the fruit fly in combination with genomic and computational methodologies. We are interested in the organizational structure of cis-regulatory modules, which includes enhancers, silencers, and insulators. We are also interested in identifying and characterizing key cis-regulatory adaptations that have occurred during the morphological diversification of animals.
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Publications
Erives, A. (2009) Non-Homologous Structured CRMs from the Ciona Genome. J. Comput. Biol. 16:369-77
Crocker, J., Erives, A. (2008) A closer look at the eve stripe 2 enhancers of Drosophila and Themira. PLoS Genetics 4:e1000276.
Crocker, J., Tamori, Y., Erives, A. (2008) Evolution acts on enhancer organization to fine-tune gradient threshold readouts. PLoS Biology 6(11): e263.
Brown, S., Cole, M., Erives, A. (2008) Evolution of the holozoan ribosome biogenesis regulon. BMC Genomics 9:442
Markstein M, et al. (2004) A regulatory code for neurogenic gene expression in the Drosophila embryo. Development 131: 2387-94.
Erives A, Levine M (2004) Coordinate enhancers share common organizational features in the Drosophila genome. Proc. Nat. Acad. Sci. USA 101:3851-6.
Stathopoulos A, et al. (2002) Whole-Genome Analysis of Dorso- Ventral Patterning in the Drosophila Embryo. Cell 111: 687-701.