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Alexandra L. Howell, Ph.D.
Title(s):
Research Associate Professor of Medicine and of Microbiology and Immunology
Department(s):
Medicine
Microbiology and Immunology
Education:
University of Texas, Ph.D., 1982
Colby College, BA, 1977
Dr. Howell received her B.A. from Colby College in 1977, and her Ph.D. from the University of Texas Graduate School of Biomedical Sciences in 1982. After postdoctoral work as a research fellow and research associate in the department of Microbiology at Dartmouth Medical School, Dr. Howell joined the faculty of the Department of Microbiology and Medicine at Dartmouth Medical School in 1984.
Programs:
Program in Experimental and Molecular Medicine
Curriculum Vitae:
Howell_A_CV_2009-02-13.pdf
NIH Biosketch:
Howell_A_BIO_2009-02-13.pdf
Websites:
http://dms.dartmouth.edu/microbio/
http://dms.dartmouth.edu/immuno/
http://dms.dartmouth.edu/pemm/
Contact Information:
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VA Medical Center Research Service 215 North Main St. White River Jct. VT 05009 |
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Office: Building T44-VA Hospital Phone: 802-295-9363 ext 5612 Fax: 802-296-5173 Email: alexandra.howell@dartmouth.edu |
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Selected Publications: |
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Mselle TF, Howell AL, Ghosh M, Wira CR, Sentman CL Asin SN, Eszterhas SK, Rollenhagen C, Heimberg AM, Howell AL Lyimo MA, Howell AL, Balandya E, Eszterhas SK, Connor RI Asin SN, Heimberg AM, Eszterhas SK, Rollenhagen C, Howell AL Howell AL, Asin SN, Yeaman GR, Wira CR Yeaman GR, Asin S, Weldon S, Demian DJ, Collins JE, Gonzalez JL, Wira CR, Fanger MW, Howell AL Asin SN, Fanger MW, Wildt-Perinic D, Ware PL, Wira CR, Howell AL Asin SN, Wildt-Perinic D, Mason SI, Howell AL, Wira CR, Fanger MW Yeager MP, Procopio MA, DeLeo JA, Arruda JL, Hildebrandt L, Howell AL |
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Professional Interests:
Our laboratory is studying the mechanisms by which sex steroid hormones, notably estradiol and progesterone, can modify HIV-1 transcription and replication in cells and tissues from the female reproductive tract. Using an ex vivo tissue explant model, we add sex hormones at concentrations that mimic those found during the menstrual cycle, and assess how varying hormone levels could modify HIV-1 reverse transcription, integration and transcription. In addition, we also study the ability of these hormones to induce the secretion of innate immune factors and inflammatory cytokines and chemokines from reproductive tract tissue explants, and their effects on HIV-1 infection and replication. Other research projects focus on expression of naturally occurring innate immune factors found in cervico-vaginal fluid, and the ability of these soluble factors to inhibit HIV-1 infection and replication.
Grant Information:
V.A. Merit Review
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