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| | | Alexandra L. Howell, Ph.D. Title(s):
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Professional Interests: Our laboratory is studying the mechanisms by which sex steroid hormones, notably estradiol and progesterone, can modify HIV-1 transcription and replication in cells and tissues from the female reproductive tract. Using an ex vivo tissue explant model, we add sex hormones at concentrations that mimic those found during the menstrual cycle, and assess how varying hormone levels could modify HIV-1 reverse transcription, integration and transcription. In addition, we also study the ability of these hormones to induce the secretion of innate immune factors and inflammatory cytokines and chemokines from reproductive tract tissue explants, and their effects on HIV-1 infection and replication. Other research projects focus on expression of naturally occurring innate immune factors found in cervico-vaginal fluid, and the ability of these soluble factors to inhibit HIV-1 infection and replication. Grant Information: V.A. Merit Review |
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