Dartmouth Medical School - Faculty Database

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Leslie P. Henderson, Ph.D.

Title(s):
Professor of Physiology and of Biochemistry

Department(s):
Biochemistry
Physiology

Education:
Stanford University, PHD 1982

Programs:
Molecular and Cellular Biology Graduate Programs
Neuroscience Center at Dartmouth
Program in Experimental and Molecular Medicine

Websites:
http://dms.dartmouth.edu/henderson/
http://dms.dartmouth.edu/pemm/faculty/a-l/
http://www.dartmouth.edu/~mcb/faculty/henderson.html
http://www.dartmouth.edu/~physiol/faculty/
http://dms.dartmouth.edu/mdphd/about/
http://dms.dartmouth.edu/ncd/

Contact Information:

Dartmouth Medical School HB 7701 Hanover NH 03755
Office: Remsen 328 Phone: 603-650-1312 Email: leslie.henderson@dartmouth.edu

Selected Publications:

Yang P, Jones BL, Henderson LP. Role of the alpha subunit in the modulation of GABA(A) receptors by anabolic androgenic steroids. Neuropharmacology. 2005 Sep;49(3):300-16. (view details on MedLine)

Penatti CA, Porter DM, Jones BL, Henderson LP. Sex-specific effects of chronic anabolic androgenic steroid treatment on GABA(A) receptor expression and function in adolescent mice. Neuroscience. 2005;135(2):533-43. (view details on MedLine)

Jones BL, Whiting PJ, Henderson LP. Mechanisms of anabolic androgenic steroid inhibition of mammalian epsilon-subunit-containing GABAA receptors. J Physiol. 2006 Jun 15;573(Pt 3):571-93. Epub 2006 Mar 16. (view details on MedLine)

Bevan CL, Porter DM, Schumann CR, Bryleva EY, Hendershot TJ, Liu H, Howard MJ, Henderson LP. The endocrine-disrupting compound, nonylphenol, inhibits neurotrophin-dependent neurite outgrowth. Endocrinology. 2006 Sep;147(9):4192-204. Epub 2006 Jun 15. (view details on MedLine)

Clark AS, Costine BA, Jones BL, Kelton-Rehkopf MC, Meerts SH, Nutbrown-Greene LL, Penatti CA, Porter DM, Yang P, Henderson LP. Sex- and age-specific effects of anabolic androgenic steroids on reproductive behaviors and on GABAergic transmission in neuroendocrine control regions. Brain Res. 2006 Dec 18;1126(1):122-38. Epub 2006 Sep 29. Review. (view details on MedLine)

Henderson LP. Steroid modulation of GABAA receptor-mediated transmission in the hypothalamus: effects on reproductive function. Neuropharmacology. 2007 Jun;52(7):1439-53. Epub 2007 Feb 28. Review. (view details on MedLine)

Jones BL, Henderson LP. Trafficking and potential assembly patterns of epsilon-containing GABAA receptors. J Neurochem. 2007 Nov;103(3):1258-71. Epub 2007 Aug 20. (view details on MedLine)

Professional Interests:

The long-term goals of my laboratory are to understand how steroids alter the expression and function of ion channel proteins involved in synaptic signalling. Our recent studies are focused on determining how anabolic androgenic steroids (AAS) act in the mammalian brain to regulate the expression and function of ă-aminobutyric acid type A (GABAA) neurotransmitter receptors, the main inhibitory receptor in the mammalian CNS and a major target of a wide range of endogenous and exogenous psychoactive drugs. To study aspects of synaptic function, we employ patch clamp recording from brain slices and isolated primary neurons of wild type and mutant mice, as well as from heterologous cells expressing different isoforms of wild type and mutant GABAA receptor subunits. We also employ piezoelectric-controlled ultrafast perfusion techniques and computer modelling to study how these drugs alter transitions of the receptors among different kinetic states. To examine how steroid influence neuronal morphology and gene expression, we employ a range of techniques including in situ hybridization, semi-quantitative and real time RT-PCR, immunohistochemistry, and Western blot analysis. In addition, our lab has a long-standing collaboration studying the effects of steroids on the brain and on behavior with Dr. Ann Clark in the Department of Psychology and Brain Science.

I am a member of the Molecular, Cellular and Systems Physiology Graduate Program, the Molecular and Cellular Biology Graduate Program, the Program in Experimental and Molecular Medicine Program and have had 3 students to date (2007) through the MD/PhD Program that was initiated at Dartmouth in 1993.

Courses Taught:

1991-present Advanced Neuroscience 150
1996-present Medical Neuroscience 115
1998-present Presidential Scholar's Program for Undergraduates
2008-present PEMM (Program in Experimental and Molecular Medicine) 271: Advanced Biology of Integrated Systems
2007-present Physiology 115: Advanced Endocrine
2006-present Program in Experimental and Molecular Medicine Core Course
(Systems Physiology lecturer)
2006 Advanced Neurobiology (Biol Sci 74): Co-instructor with RA Maue
2005 Animal Physiology (Bio 35): Guest lecturer
2004 Pathophysiology of Brain Disease
2003-2006 Molecular Cellular Biology Core Course (Biochem 103)
2001-2003 Graduate Toxicology (PharmTox 123)
1999-2002 Cell Physiology 125 (Biochemistry 144)
1998 Gastrointestinal Physiology
1996-1998 Invited Faculty Cold Spring Harbor Course on Integrative
Approaches to Ion Channel Biology
1996-2004 Pharmacology 129 (Receptors)
1993 Women in Science Program (WISP) for Undergraduates

Grant Information:

R01-DA018255: AAS and the Neurobiology of Social Behaviors
Project period: 04/01/05-03/31/10
PI: Ann S. Clark and Leslie P. Henderson (equivalent co-PIs)

R01-DA/NS14137-14 (this grant was NS28668 for years 1990-1995): Steroid Regulation of Ion Channels
NIH (NIDA)
Projected Project Period: 07/01/07-06/30/12
PI: Leslie P. Henderson

R03-DA 022716
NIH (NIDA): Interactions of Anabolic Steroids and Stress Hormones in the Forebrain
Projected Project period: 08/01/07-07/31/09
PI: Leslie Henderson
Co-I: Beth Costine

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