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Duane A. Compton, Ph.D.
Title(s):
Professor of Biochemistry
Department(s):
Biochemistry
Education:
U. Oklahoma, BS 1984
U. Texas, PHD 1988
Programs:
Molecular and Cellular Biology Graduate Programs
Contact Information:
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Dartmouth Medical School HB 7200 Hanover NH 03755 |
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Selected Publications: |
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Manning, A.L., Ganem, N.J., Bakhoum, S.F., Wagenbach, M., Wordeman, L., and Compton, D.A. The kinesin-13 proteins Kif2a, Kif2b and Kif2c/MCAK have distinct roles during mitosis in human cells. Mol. Biol. Cell. 18:2970-2979 (2007) Manning, A.L. and Compton, D.A. Mechanisms of spindle pole organizaiton are influenced by kinetochore activity in mammalian cells. Curr. Biol. 17, 260-265 (2007) Ganem, N.J., Upton, K., and Compton, D.A. Efficient mitosis in human cell lacking polewards microtubule flux. Curr. Biol. 15, 1827-1832 (2005) |
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Professional Interests:
Work in this lab is aimed at understanding how chromosomes segregate efficiently during mitosis and meiosis in vertebrate cells. Using both in vitro and in vivo approaches, the assembly and function of the microtubule-based spindle is being dissected at the molecular level. This work has led to the characterization of both structural and motor proteins that are necessary for the organization of the microtubules into spindles during mitosis and meiosis. Current work is aimed at how this process is regulated during the cell cycle and at how these proteins coordinate chromosome movement during cell division.
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