Duane A. Compton, PhD
Title(s)
Professor of Biochemistry and Cell Biology
Dean of the Medical School
Department(s)
Biochemistry and Cell Biology
Education
U. Oklahoma, BS 1984
U. Texas, PHD 1988
Programs
Academy of Master Faculty Educators
Molecular and Cellular Biology Graduate Programs
Websites
http:
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Contact Information
Geisel School of Medicine at Dartmouth
HB 7200
Hanover NH 03755
Professional Interests
Work in this lab is aimed at understanding how chromosomes segregate efficiently during mitosis and meiosis in vertebrate cells. Using both in vitro and in vivo approaches, the assembly and function of the microtubule-based spindle is being dissected at the molecular level. This work has led to the characterization of both structural and motor proteins that are necessary for the organization of the microtubules into spindles during mitosis and meiosis. Current work is aimed at how this process is regulated during the cell cycle and at how these proteins coordinate chromosome movement during cell division.
Mentoring Information
Duane would be happy to mentor faculty about teaching in large or small group environments, directing a course, and mentoring graduate students.
Biography
Duane has contributed lectures and small group discussions to Biochem 110, the Biochemical and Genetic Basis of Medicine, for first year medical students. He served as course director for Biochem 110 for many years. Duane also contributed lectures to Biochem 103, the third term of the MCB core course for first year graduate students. He served as course director for that course for many years. Duane has mentored 13 graduate students to the completion of their PhDs.
Cyclin A/Cdk1 promotes chromosome alignment and timely mitotic progression. An Aurora kinase A-BOD1L1-PP2A B56 Axis promotes chromosome segregation fidelity. A pluripotent developmental state confers a low fidelity of chromosome segregation. Small changes in phospho-occupancy at the kinetochore-microtubule interface drive mitotic fidelity. Identifying Cyclin A/Cdk1 Substrates in Mitosis in Human Cells. A comparative analysis of methods to measure kinetochore-microtubule attachment stability. Chromosomal instability suppresses the growth of K-Ras-induced lung adenomas. Single-cell RNA sequencing reveals the impact of chromosomal instability on glioblastoma cancer stem cells. Quantitative methods to measure aneuploidy and chromosomal instability. Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability. |
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