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William F. Hickey, M.D.

Title(s):
The John La Porte Given Professor and Professor of Pathology

Department(s):
Microbiology and Immunology
Pathology

Education:
Tufts University, BSE 1972
Tufts University, BS 1972
Tufts University, MA 1972
U. Vermont College of Medicine, MD 1977

Programs:
Neuroscience Center at Dartmouth
Program in Experimental and Molecular Medicine

Websites:
http://dms.dartmouth.edu/ncd/

Contact Information:

Department of Pathology
Dartmouth-Hitchcock Medical Center
One Medical Center Drive
Lebanon NH 03756
Office: Borwell, 508W
Phone: 603-650-4805
Fax: 603-650-6120
Email: William.Hickey@dartmouth.edu


Selected Publications:

 

Bryleva EY, Rogers MA, Chang CC, Buen F, Harris BT, Rousselet E, Seidah NG, Oddo S, Laferla FM, Spencer TA, Hickey WF, Chang TY
ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD.
Proc Natl Acad Sci U S A 2010 Jan 26;
PMID: 20133765 [PubMed - as supplied by publisher]

Reid PC, Lin S, Vanier MT, Ohno-Iwashita Y, Harwood HJ Jr, Hickey WF, Chang CC, Chang TY
Partial blockage of sterol biosynthesis with a squalene synthase inhibitor in early postnatal Niemann-Pick type C npcnih null mice brains reduces neuronal cholesterol accumulation, abrogates astrogliosis, but may inhibit myelin maturation.
J Neurosci Methods 2008 Feb 15; 168(1):15-25
PMID: 17949821 [PubMed - indexed for MEDLINE]

Macleod JE, DeLeo JA, Hickey WF, Ahles TA, Saykin AJ, Bucci DJ
Cancer chemotherapy impairs contextual but not cue-specific fear memory.
Behav Brain Res 2007 Jul 19; 181(1):168-72
PMID: 17509697 [PubMed - indexed for MEDLINE]

Davidson TS, Longnecker DS, Hickey WF
An experimental model of autoimmune pancreatitis in the rat.
Am J Pathol 2005 Mar; 166(3):729-36
PMID: 15743785 [PubMed - indexed for MEDLINE]

Davidson TS, Hickey WF
Antisecretory factor expression is regulated by inflammatory mediators and influences the severity of experimental autoimmune encephalomyelitis.
J Leukoc Biol 2004 Oct; 76(4):835-44
PMID: 15277566 [PubMed - indexed for MEDLINE]

Davidson TS, Hickey WF
Distribution and immunoregulatory properties of antisecretory factor.
Lab Invest 2004 Mar; 84(3):307-19
PMID: 14767482 [PubMed - indexed for MEDLINE]

Reid PC, Sakashita N, Sugii S, Ohno-Iwashita Y, Shimada Y, Hickey WF, Chang TY
A novel cholesterol stain reveals early neuronal cholesterol accumulation in the Niemann-Pick type C1 mouse brain.
J Lipid Res 2004 Mar; 45(3):582-91
PMID: 14703504 [PubMed - indexed for MEDLINE]

Pekala JS, Mamourian AC, Wishart HA, Hickey WF, Raque JD
Focal lesion in the splenium of the corpus callosum on FLAIR MR images: a common finding with aging and after brain radiation therapy.
AJNR Am J Neuroradiol 2003 May; 24(5):855-61
PMID: 12748085 [PubMed - indexed for MEDLINE]

Tobias SM, Robitaille Y, Hickey WF, Rhodes CH, Nordgren R, Andermann F
Bilateral Rasmussen encephalitis: postmortem documentation in a five-year-old.
Epilepsia 2003 Jan; 44(1):127-30
PMID: 12581240 [PubMed - indexed for MEDLINE]

Sweitzer SM, Hickey WF, Rutkowski MD, Pahl JL, DeLeo JA
Focal peripheral nerve injury induces leukocyte trafficking into the central nervous system: potential relationship to neuropathic pain.
Pain 2002 Nov; 100(1-2):163-70
PMID: 12435469 [PubMed - indexed for MEDLINE]


Professional Interests:

Neuroimmunology

Courses Taught:

Director of General Pathology Course for DMS Year 1 Students

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