Eck SM, Blackburn JS, Schmucker AC, Burrage PS, Brinckerhoff CE Matrix metalloproteinase and G protein coupled receptors: co-conspirators in the pathogenesis of autoimmune disease and cancer. J Autoimmun 2009 Nov-Dec; 33(3-4):214-21 PMID: 19800199 [PubMed - in process]
Eck SM, Cote AL, Winkelman WD, Brinckerhoff CE CXCR4 and matrix metalloproteinase-1 are elevated in breast carcinoma-associated fibroblasts and in normal mammary fibroblasts exposed to factors secreted by breast cancer cells. Mol Cancer Res 2009 Jul; 7(7):1033-44 PMID: 19584257 [PubMed - in process]
Coon CI, Fiering S, Gaudet J, Wyatt CA, Brinckerhoff CE Site controlled transgenic mice validating increased expression from human matrix metalloproteinase (MMP-1) promoter due to a naturally occurring SNP. Matrix Biol 2009 Sep; 28(7):425-31 PMID: 19577645 [PubMed - in process]
Petrella BL, Brinckerhoff CE PTEN suppression of YY1 induces HIF-2 activity in von hippel lindau null renal cell carcinoma. Cancer Biol Ther 2009 Jul; 8(14):1389-401 PMID: 19483472 [PubMed - in process]
Burrage PS, Schmucker AC, Ren Y, Sporn MB, Brinckerhoff CE Retinoid X receptor and peroxisome proliferator-activated receptor-gamma agonists cooperate to inhibit matrix metalloproteinase gene expression. Arthritis Res Ther 2008; 10(6):R139 PMID: 19046432 [PubMed - indexed for MEDLINE]
Blackburn JS, Brinckerhoff CE Matrix metalloproteinase-1 and thrombin differentially activate gene expression in endothelial cells via PAR-1 and promote angiogenesis. Am J Pathol 2008 Dec; 173(6):1736-46 PMID: 18988801 [PubMed - indexed for MEDLINE]
Vincenti MP, Brinckerhoff CE Signal transduction and cell-type specific regulation of matrix metalloproteinase gene expression: can MMPs be good for you? J Cell Physiol 2007 Nov; 213(2):355-64 PMID: 17654499 [PubMed - indexed for MEDLINE]
Burrage PS, Huntington JT, Sporn MB, Brinckerhoff CE Regulation of matrix metalloproteinase gene expression by a retinoid X receptor-specific ligand. Arthritis Rheum 2007 Mar; 56(3):892-904 PMID: 17328062 [PubMed - indexed for MEDLINE]
Petrella BL, Brinckerhoff CE Tumor cell invasion of von Hippel Lindau renal cell carcinoma cells is mediated by membrane type-1 matrix metalloproteinase. Mol Cancer 2006 Dec 1; 5():66 PMID: 17140440 [PubMed - indexed for MEDLINE]
Wyatt CA, Geoghegan JC, Brinckerhoff CE Short hairpin RNA-mediated inhibition of matrix metalloproteinase-1 in MDA-231 cells: effects on matrix destruction and tumor growth. Cancer Res 2005 Dec 1; 65(23):11101-8 PMID: 16322260 [PubMed - indexed for MEDLINE]
Professional Interests:
Research focuses on the molecular and cellular mechanisms by which the Matrix Metalloproteinases (MMPs), enzymes that degrade the extracellular matrix at neutral pH, facilitate the invasive and metastatic behavior of tumor cells. In most normal cells, constitutive expression of MMPs is low, but increases in response to cytokines and growth factors. In some tumors (e.g., breast cancer and melanoma), however, MMP expression is constutively high, and the high expression enhances their invasiveness. This lab is using a novel invasion assay to monitor the invasion of tumor cells through the extracellular matrix and to document the efficacy of novel agents that suppress MMPs to also suppress invasion and metastasis.
Grant Information:
AR-26599-28. Regulation of Collagenase Gene Expression
CA-77267-07. Invasive Behavior of Tumor cells Producing Collagenase-1
