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J. Andrew Daubenspeck, Ph.D.
Title(s):
Professor of Physiology
Adjunct Professor of Biomedical Engineering
Department(s):
Physiology
Education:
Dartmouth College, Ph.D. 1972
Programs:
Program in Experimental and Molecular Medicine
Websites:
http://www.dartmouth.edu/~physiol/faculty/index.htm
Contact Information:
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Physiology Department HB7700 Dartmouth Medical School Lebanon, NH 03756 |
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Office: Room 730E, Borwell Research Building Phone: 603/650-7727 Fax: 603/650-6130 Email: andy.daubenspeck@dartmouth.edu |
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Selected Publications: |
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Daubenspeck JA, Manning HL, Akay M. Contribution of supraglottal mechanoreceptor afferents to respiratory-related evoked potentials in humans. J Appl Physiol. 2000 Jan;88(1):291-9. (view details on MedLine) Daubenspeck JA, Lim LM, Akay M. Global field power helps to separate respiratory-related evoked potentials from electromyographic contamination. J Appl Physiol. 2000 Jan;88(1):282-90. (view details on MedLine) Akay M, Daubenspeck JA. Effect of supraglottic mechanoreceptors on spatial mapping of respiratory related evoked responses using wavelet and Laplacian methods. Ann Biomed Eng. 2000 Nov-Dec;28(11):1370-80. (view details on MedLine) Krause WL, Leiter JC, Marsh Tenney S, Daubenspeck JA. Acute hypoxia activates human 8-12 Hz physiological tremor. Respir Physiol. 2000 Oct;123(1-2):131-41. (view details on MedLine) BuSha BF, Judd BG, Manning HL, Simon PM, Searle BC, Daubenspeck JA, Leiter JC. Identification of respiratory vagal feedback in awake normal subjects using pseudorandom unloading. J Appl Physiol. 2001 Jun;90(6):2330-40. (view details on MedLine) Daubenspeck JA, Manning HL, Baird JC. Midlatency respiratory-related somatosensory activity and perception of oral pressure pulses in normal humans. J Appl Physiol. 2001 Jun;90(6):2048-56. (view details on MedLine) Akay M, Leiter JC, Daubenspeck JA. Reduced respiratory-related evoked activity in subjects with obstructive sleep apnea syndrome.Reduced respiratory-related evoked activity in subjects with obstructive sleep apnea syndrome. J Appl Physiol. 2003 Feb;94(2):429-38. Epub 2002 Dec 20. (view details on MedLine) Chernov MM, Daubenspeck JA, Denton JS, Pfeiffer JR, Putnam RW, Leiter JC. A computational analysis of central CO2 chemosensitivity in Helix aspersa. Am J Physiol Cell Physiol. 2007 Jan;292(1):C278-91. Epub 2006 Aug 23. (view details on MedLine) Daubenspeck JA. Respiratory-related evoked potentials. Wiley Encyclopedia of Biomedical Engineering (Metin Akay, ed.), Hoboken: John Wiley and Sons, Inc., April 2006. www.mrw.interscience.wiley.com/ebe/articles/ebs1039/frame.html Daubenspeck JA, Li A, Nattie EE. Acoustic plethysmography measures breathing in unrestrained neonatal mice. J Appl Physiol. 2008 Jan;104(1):262-8. Epub 2007 Oct 25. (view details on MedLine) |
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Professional Interests:
Dr. Daubenspeck has been interested in the neural processes involved in regulation of the respiratory pattern of humans with respect to the influence of the mechanics of the respiratory system.
Dr. Daubenspeck has investigated the role of upper airway mechanoreceptors that provide feedback to control upper airway muscles, holding the compliant airway open against the collapsing tendency of the negative pressures required for inspiratory flow.
His research group developed a new approach for assessing information coming to the human brain from peripheral mechanoreceptors. By measuring tiny, evoked electrical potentials on the scalp within 25-80 milliseconds of pressure pulses applied at the mouth, they were able to evaluate mechanosensation. This provided a non-invasive window into the feedback information coming to the respiratory controller from peripheral receptors. This information is useful in evaluation of pathological conditions that influence respiratory pattern regulation and the perception of respiratory discomfort in patients.
Recently, Dr. Daubenspeck's research interests have turned to the evaluation of cardiorespiratory control as indicated by the nature of the beat-to-beat variability in the cardiac rhythm. Since regulation of the heart rate involves a host of important regulation pathways in the central nervous system, abnormalities in those control mechanisms will be reflected in changes in the character of heart rate variability. This approach is being applied to data obtained from neonatal piglets representing a possible model of Sudden Infant Death Syndrome (SIDS) and to data from newborn human infants obtained from the CHIME study.
Courses Taught:
Engs 51: Principles of System Dynamics
Engg 166: Physiology for Bioengineers
Engg 266: Physiological Systems Modeling
Medical Physiology 110: Cardiorespiratory physiology (with others)
Physiology 125: Critical Reading of the Scientific Literature (with others)
Grant Information:
SIDS Program Project Grant (co-investigator with Dr. Hannah Kinney, PI)
CHIME HRV in Arousals Project (co-investigator with Dr. Robert Darnall, PI)
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