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Risto A. Kauppinen, M.D., Ph.D.

Title(s):
Director, Biomedical NMR Research Center
Professor of Radiology

Department(s):
Radiology

Programs:
Program in Experimental and Molecular Medicine

Contact Information:

706 Vail, HB7785
Dartmouth Medical School
Hanover NH 03755
Office: 706 Vail
Phone: 603-650-1677
Fax: 603-650-1717
Email: risto.a.kauppinen@dartmouth.edu


Selected Publications:

 

  • Mäkelä HI, Kettunen MI, Gröhn OH, Kauppinen RA. Quantitative T(1rho) and magnetization transfer magnetic resonance imaging of acute cerebral ischemia in the rat. J Cereb Blood Flow Metab. 2002 May;22(5):547-58. (view details on MedLine)

  • Tuunanen PI, Kavec M, Jousmäki V, Usenius JP, Hari R, Salmelin R, Kauppinen RA. Comparison of BOLD fMRI and MEG characteristics to vibrotactile stimulation. Neuroimage. 2003 Aug;19(4):1778-86. (view details on MedLine)

  • Griffin JL, Lehtimäki KK, Valonen PK, Gröhn OH, Kettunen MI, Ylä-Herttuala S, Pitkänen A, Nicholson JK, Kauppinen RA. Assignment of 1H nuclear magnetic resonance visible polyunsaturated fatty acids in BT4C gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death. Cancer Res. 2003 Jun 15;63(12):3195-201. (view details on MedLine)

  • Lehtimäki KK, Valonen PK, Griffin JL, Väisänen TH, Gröhn OH, Kettunen MI, Vepsäläinen J, Ylä-Herttuala S, Nicholson J, Kauppinen RA. Metabolite changes in BT4C rat gliomas undergoing ganciclovir-thymidine kinase gene therapy-induced programmed cell death as studied by 1H NMR spectroscopy in vivo, ex vivo, and in vitro. J Biol Chem. 2003 Nov 14;278(46):45915-23. Epub 2003 Sep 3. (view details on MedLine)

  • Kavec M, Usenius JP, Tuunanen PI, Rissanen A, Kauppinen RA. Assessment of cerebral hemodynamics and oxygen extraction using dynamic susceptibility contrast and spin echo blood oxygenation level-dependent magnetic resonance imaging: applications to carotid stenosis patients. Neuroimage. 2004 May;22(1):258-67. (view details on MedLine)

  • Kavec M, Gröhn OH, Gröhn HI, Garwood M, Kauppinen RA. Dynamic dephasing changes in developing ischemic cerebral infarction in rats studied by Carr-Purcell T2 magnetic resonance imaging. Magn Reson Med. 2005 Apr;53(4):960-4. (view details on MedLine)

  • Griffin JL, Blenkiron C, Valonen PK, Caldas C, Kauppinen RA. High-resolution magic angle spinning 1H NMR spectroscopy and reverse transcription-PCR analysis of apoptosis in a rat glioma. Anal Chem. 2006 Mar 1;78(5):1546-52. (view details on MedLine)

  • Kettunen MI, Sierra A, Närväinen MJ, Valonen PK, Ylä-Herttuala S, Kauppinen RA, Gröhn OH. Low spin-lock field T1 relaxation in the rotating frame as a sensitive MR imaging marker for gene therapy treatment response in rat glioma. Radiology. 2007 Jun;243(3):796-803. (view details on MedLine)

  • Denes A, Vidyasagar R, Feng J, Narvainen J, McColl BW, Kauppinen RA, Allan SM. Proliferating resident microglia after focal cerebral ischaemia in mice. J Cereb Blood Flow Metab. 2007 Dec;27(12):1941-53. Epub 2007 Apr 18. (view details on MedLine)

  • Kauppinen RA, Vidyasagar R, Childs C, Balanos GM, Hiltunen Y. Assessment of human brain temperature by (1)H MRS during visual stimulation and hypercapnia. NMR Biomed. 2008 May;21(4):388-95. (view details on MedLine)


  • Professional Interests:

    MRI and MRS techniques, Brain tumours, Cerebral haemodynamics

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