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Yolanda Sanchez, Ph.D.
Title(s):
Associate Professor
Department(s):
Pharmacology and Toxicology
Education:
Ph.D. Graduate School of Biomedical Sciences Houston, TX. Postdoctoral training Baylor College of Medicine
Programs:
Program in Experimental and Molecular Medicine
Websites:
http://www.dartmouth.edu/~sanchezlab/
Contact Information:
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Dartmouth Medical School, HB 7650 Hanover NH 03755 |
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Office: Vail 501 Phone: 603-650-1669 Fax: 603-650-1129 Email: yolanda.sanchez@dartmouth.edu |
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Selected Publications: |
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Caldwell JM, Chen Y, Schollaert KL, Theis JF, Babcock GF, Newlon CS, Sanchez Y. Orchestration of the S-phase and DNA damage checkpoint pathways by replication forks from early origins. J Cell Biol. 2008 Mar 24;180(6):1073-86. Epub 2008 Mar 17. (view details on MedLine) Chen Y, Pereira E, Sanchez Y. Chk1. AfCS-Nature Molecule Pages (2007). (doi:10.1038/mp.a000642.01) Searle J S and Sanchez Y. Dissecting layers of mitotic regulation essential for maintaining genomic stability. Yeast as a tool in cancer research. Heitman, J., and Nitiss, J. L ed. Springer, 2007 Chen Y, Sanchez Y. Chk1 in the DNA damage response: conserved roles from yeasts to mammals. DNA Repair (Amst). 2004 Aug-Sep;3(8-9):1025-32. Review. (view details on MedLine) Schollaert KL, Poisson JM, Searle JS, Schwanekamp JA, Tomlinson CR, Sanchez Y. A role for Saccharomyces cerevisiae Chk1p in the response to replication blocks. Mol Biol Cell. 2004 Sep;15(9):4051-63. Epub 2004 Jun 30. (view details on MedLine) Searle JS, Schollaert KL, Wilkins BJ, Sanchez Y. The DNA damage checkpoint and PKA pathways converge on APC substrates and Cdc20 to regulate mitotic progression. Nat Cell Biol. 2004 Feb;6(2):138-45. Epub 2004 Jan 25 (view details on MedLine) Goudelock DM, Jiang K, Pereira E, Russell B, Sanchez Y. Regulatory interactions between the checkpoint kinase Chk1 and the proteins of the DNA-dependent protein kinase complex. J Biol Chem. 2003 Aug 8;278(32):29940-7. Epub 2003 May 19. (view details on MedLine) Jiang K, Pereira E, Maxfield M, Russell B, Goudelock DM, Sanchez Y. Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345. J Biol Chem. 2003 Jul 4;278(27):25207-17. Epub 2003 Apr 3. (view details on MedLine) Sanchez Y, Bachant J, Wang H, Hu F, Liu D, Tetzlaff M, Elledge SJ. Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms. Science. 1999 Nov 5;286(5442):1166-71. (view details on MedLine) Sanchez Y, Wong C, Thoma RS, Richman R, Wu Z, Piwnica-Worms H, Elledge SJ. Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. Science. 1997 Sep 5;277(5331):1497-501. (view details on MedLine) |
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Professional Interests:
Checkpoint signaling events triggered during the response to DNA damage or replication interference, how they regulate cell cycle progression, DNA repair and cell death. The role of checkpoints in the etiology of cancer and as drug targets for therapeutic enhancers of genotoxic cancer drugs.
Specific Interests:
1. The role of checkpoints in embryonic development
2. Optimization of model organisms for high-throughput drug discovery
3. The interplay of Oncogenes and Checkpoints during cancer development
4. Regulation of mitosis by localized activation of enzyme complexes
5. Dissection of signal transduction pathways originating at a stalled replication fork
Courses Taught:
PEMM Core Course
Graduate Toxicology
Medical Pharmacology
Grant Information:
NIH NCI RO1 CA84463
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