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Paul J. Beisswenger, M.D.

Contact Information:

Professional Interests:

My research program is focused on determining the role of enzymatic control of non-enzymatic glycation in the cellular and tissue damage associated with diabetes. My focus is on factors that regulate toxic oxidative and dicarbonyl compounds, and their resultant Advanced oxidative and Glycation Endproducts (AGEs), both of which are produced in excess in diabetes and play an important role in the development of diabetic complications. My laboratory is also at the very forefront of research in the new area of enzymatic deglycation in mammalian systems. My most recent research funding has been provided to study biomarkers that can potentially predict susceptibility to diabetic vascular complications. We have recently obtained a triple quad LC/MS-MS that can quantify a number of AGEs and oxidative products. With these tools we are in a unique position to combine studies of human populations with powerful analytic laboratory techniques and new paradigms to address some of the important outstanding questions regarding diabetic complications.

Courses Taught:

Scientific Basis of Medicine, Endocrine section-Director
Weekly Endocrine Research Conference
PEMM 101/102
ADVANCED ENDOCRINOLOGY COURSE (Physiology)

Grant Information:

Glycation/Oxidative Biomarkers, Glucose Patterns, and Diabetic Nephropathy
JDRF Grant Number: 17-2008-899
Academic Research and Development Grant, Juvenile Diabetes Research Foundation Sept 1 2008-August 31 2010 has been received to fully fund my research.