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Allan T. Gulledge, Ph.D.
Title(s):
Assistant Professor of Physiology
Department(s):
Physiology
Education:
University of California, Riverside, BS 1991
University of Texas, San Antonio, PhD 2000
Programs:
Neuroscience Center at Dartmouth
Program in Experimental and Molecular Medicine
Websites:
http://www.dartmouth.edu/~gulledge
http://www.dartmouth.edu/~physiol/faculty/gulledge.html
http://dms.dartmouth.edu/ncd/
http://dms.dartmouth.edu/pemm/
Contact Information:
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Dartmouth Medical School Dartmouth Hitchcock Medical Center, Borwell 740E One Medical Center Drive Lebanon NH 03756-0001 |
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Office: Borwell 704E Phone: 603-650-7283 Fax: 603-650-6130 Email: allan.gulledge@dartmouth.edu Asst. Phone: 603-650-7731 |
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Selected Publications: |
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Gulledge AT, Stuart GJ. Excitatory actions of GABA in the cortex. Neuron 37:299-309, 2003. (view details on MedLine) Gulledge AT, Stuart GJ. Action potential initiation and propagation in layer 5 pyramidal neurons of the rat prefrontal cortex: absence of dopamine modulation. J Neurosci. 23:11363-72, 2003. (view details on MedLine) Gulledge AT, Stuart GJ Cholinergic inhibition of neocortical pyramidal neurons. J. Neurosci. 25:10308-10320, 2005. (view details on MedLine) Gulledge AT, Park SB, Kawaguchi Y, Stuart GJ Heterogeneity of phasic cholinergic signaling in neocortical neurons. J. Neurophysiol. 97:2215-2229, 2007. (view details on MedLine) Gulledge AT, Kawaguchi Y Phasic cholinergic signaling in the hippocampus: functional homology with the neocortex? Hippocampus 17:327-332, 2007. (view details on MedLine) Gulledge AT, Bucci DJ, Zhang SS, Matsui M, and Yeh HH M1 receptors mediate cholinergic modulation of excitability in neocortical pyramidal neurons. J. Neurosci. 29:9888–9902, 2009. (view details on MedLine) |
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Professional Interests:
Our research focus is the cerebral cortex, an area of the brain that serves as the biological substrate for the higher cognitive functions that define us as individuals. We wish to identify the mechanisms by which individual cortical neurons process and transmit information within the cortical circuit. To accomplish this we employ electrical and optical recording techniques that measure neuronal activity in individual neocortical neurons under a variety of experimental conditions.
Currently we are investigating the signal transduction events initiated following exposure of neurons to chemical neuromodulators critical for normal cognition. These modulators (such as dopamine, serotonin, and acetylcholine) activate a number of receptor subtypes to initiate a variety of biochemical signaling cascades within neurons. We are conducting experiments to identify which receptors and cellular processes are activated by neuromodulators, and how these signaling systems interact to influence ongoing neuronal activity. Because there are many different cell types within the cortex, each expressing a unique combination of receptors and intracellular biochemistry, neuromodulators tend to generate cell-type specific responses. By examining how individual neuromodulators differentially regulate the activity of many types of cortical neuron, we aim to identify the functional role of modulators within the cortical circuit, and to gain insight into their contribution to cognitive function.
Courses Taught:
Advanced Systems Physiology (PEMM 271)
Medical Neuroscience (MDED 115)
Cardiovascular and Respiratory Physiology (PHSL.110)
Grant Information:
R01-MH083806: Cholinergic signaling in cortical neurons: a unifying hypothesis
Project period: 07/11/08-06/30/12
PI: Allan Gulledge
NSF 0922631: MRI: Acquisition of a multi-photon imaging and electrophysiology rig
Project period: 08/01/2009 - 07/31/2012
PI: Allan Gulledge
NARSAD Young Investigator Award (2009): CCK-Positive Large Basket Neurons as a Source of Cortical Activation in ADHD
Project Period: 01/01/2010 - 12/31/2012
PI: Allan Gulledge
Neuroscience Center at Dartmouth Collaborative/Translational Funding Award: Cholinergic mechanisms involved in cue discrimination
Project Period: 01/01/2008 - 01/01/2009
PI: Allan Gulledge & David Bucci
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