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Hermes Hsiao-Mei Yeh, Ph.D.
Title(s):
William W. Brown Professor and Chair of Physiology
Department(s):
Physiology
Education:
1972 - 1976 B.A. DePauw University, Greencastle, IN (Zoology & Physical Chemistry)
1976 - 1981 Ph.D. University of Texas Health, Southwestern Med. Ctr., Dallas, TX (Cell Biology/Neuroscience)
1981 - 1984 Postdoc. Staff Fellow, Laboratory of Vision Research, NEI, NIH, Bethesda, MD (Retinal Neurobiology)
Programs:
Program in Experimental and Molecular Medicine
Contact Information:
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Department of Physiology, HB 7700 One Medical Center Drive Lebanon NH 03756 |
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Office: 700 E Borwell Building Phone: 603-650-7798 Fax: 603-650-7716 Email: hermes.yeh@dartmouth.edu Asst. Phone: 603-650-6139 |
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Selected Publications: |
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Cheng Q, Yeh HH. Brain-derived neurotrophic factor attenuates mouse cerebellar granule cell GABA(A) receptor-mediated responses via postsynaptic mechanisms. J Physiol. 2003 May 1;548(Pt 3):711-21. Epub 2003 Mar 14. (view details on MedLine) Chan CH, Yeh HH. Enhanced GABA(A) receptor-mediated activity following activation of NMDA receptors in Cajal-Retzius cells in the developing mouse neocortex. J Physiol. 2003 Jul 1;550(Pt 1):103-11. Epub 2003 May 2. (view details on MedLine) van Zundert B, Alvarez FJ, Tapia JC, Yeh HH, Diaz E, Aguayo LG. Developmental-dependent action of microtubule depolymerization on the function and structure of synaptic glycine receptor clusters in spinal neurons. J Neurophysiol. 2004 Feb;91(2):1036-49. Epub 2003 Sep 10. (view details on MedLine) Wu CW, Yeh HH. Nerve growth factor rapidly increases muscarinic tone in mouse medial septum/diagonal band of Broca. J Neurosci. 2005 Apr 27;25(17):4232-42. (view details on MedLine) Cuzon VC, Yeh PW, Cheng Q, Yeh HH. Ambient GABA promotes cortical entry of tangentially migrating cells derived from the medial ganglionic eminence. Cereb Cortex. 2006 Oct;16(10):1377-88. Epub 2005 Dec 7. (view details on MedLine) Cheng Q, Yeh PW, Yeh HH. Cajal-Retzius cells switch from expressing gamma-less to gamma-containing GABA receptors during corticogenesis. Eur J Neurosci. 2006 Oct;24(8):2145-51. (view details on MedLine) Johnson EM, Craig ET, Yeh HH. TrkB is necessary for pruning at the climbing fibre-Purkinje cell synapse in the developing murine cerebellum. J Physiol. 2007 Jul 15;582(Pt 2):629-46. Epub 2007 Apr 26. (view details on MedLine) Cuzon VC, Yeh PW, Yanagawa Y, Obata K, Yeh HH. Ethanol consumption during early pregnancy alters the disposition of tangentially migrating GABAergic interneurons in the fetal cortex. J Neurosci. 2008 Feb 20;28(8):1854-64. (view details on MedLine) Lee H, Raiker SJ, Venkatesh K, Geary R, Robak LA, Zhang Y, Yeh HH, Shrager P, Giger RJ. Synaptic function for the Nogo-66 receptor NgR1: regulation of dendritic spine morphology and activity-dependent synaptic strength. J Neurosci. 2008 Mar 12;28(11):2753-65. (view details on MedLine) |
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Professional Interests:
Dr. Yeh received the Ph.D. degree in Cell Biology with concentration in Neuroscience from the University of Texas Southwestern Medical Center at Dallas in 1981. His research interests are neuroscience-oriented. The PHS-funded research projects are representative of his research directions and have laid the groundwork for other ongoing projects in his laboratory. The first project investigates the role of GABA as a developmental neurotransmitter in regulating tangential migration at embryonic stages of corticogenesis. This project has been extended to examining in transgenic mice harboring a TrkB receptor loss-of-function the role of brain-derived neurotrophic factor (BDNF) in regulating the development of inhibitory and excitatory synaptic transmission during cerebellar development. A companion project examines the rapid and acute neuromodulator-like effect of BDNF on synaptic transmission. The second project seeks to delineate the cellular and molecular mechanisms underlying altered synaptic plasticity along the septohippocampal system following an intrahippocampal gain of nerve growth factor (NGF) function. The third project is aimed at understanding the cellular and molecular mechanisms underlying the well-known learning and memory deficits in chronic alcoholism. Graduate students are encouraged to use these projects as template and steppingstone to explore and develop their own research directions.
Dr. Yeh has taught actively in the medical school and graduate school curricula, and has had leadership roles in directing graduate education and training at the institutional and national levels.
Courses Taught:
Medical Human Gross Anatomy (U. Rochester Sch. Med.) 1984-1992
Neurobiology for undergraduate neuroscience majors (U. Rochester) 1989-1991
Experimental Neuroscience (U. Rochester Sch. Med.) 1988-1990
Medical Physiology (1st. yr Med. Sch., Bowman Gray Sch. Med.) 1993-1995
Medical Pharmacology (2nd. yr Med. Sch., Bowman Gray Sch. Med.) 1994-1995
Developmental Neuroscience (Bowman Gray Sch. Med.) 1992-1995
Advanced Physiology for graduate students (Bowman Gray) 1992-1995
Neuroscience Special Topics Tutorial (Bowman Gray Sch. Med.) 1992-1995
Integrative Graduate Neuroscience (Bowman Gray Sch. Med.) 1992-1995
Mechanisms of Disease, (2nd yr. Med. Sch., UCHC) 1995-1999
Section Leader: Diseases of the Nervous System 1997-1999
Cellular and Molecular Neuroscience (Grad. Sch., UCHC) 1996-2000
Systems Neuroscience (Grad. Sch., UCHC) 1996-2000
Pharmacology Core Course (Grad. Sch., UCHC) 1996-2000
Cellular Neuroscience (Grad. Sch., U. Rochester SMD), Coordinator, Section on Developmental Neuroscience 2000-2005
Ethics and Professional Integrity (U. Rochester SMD), Co-Director 2000-2005
PBL, Humans Structure and Function (1st. yr. SMD), U. Rochester 2001-2005
PBL, Mechanisms of Drug Action (2nd. Yr. SMD), U. Rochester 2000-2005
Program in Experimental and Molecular Medicine Core Course, DMS 2006-
Program in Experimental and Molecular Medicine PEMM 271, DMS 2008-
Grant Information:
RO1 NS048603, Yeh, Hermes H. (PI)
NIH/NINDS
“ The Septohippocampal System: Regulation by Neurotrophins”
R01 MH69826, Yeh, Hermes H. (PI) NIH/NIMH
“Tangentially Migrating Neurons During Corticogenesis”
R01 AA014698, Yeh, Hermes H. (PI)
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