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Stephen L Lee, M.D., Ph.D.
Title(s):
Assistant Professor of Medicine (Neurology)
Department(s):
Medicine
Education:
Washington University School of Medicine, Ph.D. 1997
Washington University School of Medicine, M.D. 1997
Programs:
Neuroscience Center at Dartmouth
Program in Experimental and Molecular Medicine
Websites:
http://dms.dartmouth.edu/ncd/
Contact Information:
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Department of Medicine One Medical Center Drive - HB 7500 Lebanon NH 03756 |
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Office: 564E Borwell Phone: 603-650-8355 Fax: 603-650-6233 Email: stephen.l.lee@dartmouth.edu Assistant: Susan A. Mitchell Asst. Phone: 650-5105 |
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Selected Publications: |
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Lee SL, Murdock DG, McCauley JL, Bradford Y, Crunk A, McFarland L, Jiang L, Wang T, Schnetz-Boutaud N, Haines JL. A Genome-wide Scan in an Amish Pedigree with Parkinsonism. Ann Hum Genet. 2008 May 26. [Epub ahead of print] (view details on MedLine) Motsinger AA, Lee SL, Mellick G, Ritchie MD. GPNN: power studies and applications of a neural network method for detecting gene-gene interactions in studies of human disease. BMC Bioinformatics. 2006 Jan 25;7:39. (view details on MedLine) Galvin JE, Lee SL, Perry A, Havlioglu N, McKeel DW Jr, Morris JC. Familial dementia with Lewy bodies: clinicopathologic analysis of two kindreds. Neurology. 2002 Oct 8;59(7):1079-82. (view details on MedLine) Charles PD, Van Blercom N, Krack P, Lee SL, Xie J, Besson G, Benabid AL, Pollak P. Predictors of effective bilateral subthalamic nucleus stimulation for PD. Neurology. 2002 Sep 24;59(6):932-4. (view details on MedLine) Lee SL, Sadovsky Y, Swirnoff AH, Polish JA, Goda P, Gavrilina G, Milbrandt J Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1). Science. 1996: Aug 30;273(5279):1219-21. (view details on MedLine) Lee SL, Wesselschmidt RL, Linette GP, Kanagawa O, Russell JH, Milbrandt J. Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFI-B (Nur77) Science. 1995: Jul 28; 269: pp. 532-5. (view details on MedLine) |
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Professional Interests:
Dr. Lee's laboratory seeks to understand the molecular pathogenesis of Parkinson’s disease and other neurodegenerative disorders.
The approach of this laboratory is to apply molecular, cellular, and model organism studies to explore the biological function of genes identified in human genetics. Insights gained from this approach will identify molecular mechanisms that underlie neurodegenerative diseases and highlight therapeutic targets that may be translated ultimately into novel therapies.
Courses Taught:
Lecturer, Pathophysiological Basis of Brain Diseases
Lecturer, DMS Neuroscience (ND115)
Lecturer, Genetics and Physiology of Behavior (Genetics 142 /Bio 79)
Lecturer, Experimental and Molecular Medicine I (PEMM 101)
Grant Information:
K08 NS044298 (PI)
NIH/NINDS
Genetic Analysis of an Amish Family with Parkinsonism
Translational/Collaborative Grant (PI)
Neuroscience Center at Dartmouth
Targeting Parkinson’s disease genes by RNA interference: Neurochemical and neurobehavioral analysis.
Clinical Discovery Award (PI: Haines JL)
Michael J. Fox Foundation
Parkinson disease in Ohio Amish
Information and Referral Center (Co-Medical Director: Coffey DJ)
American Parkinson Disease Association
Dartmouth College Strategy 4 (Co-PI: Holmes GL)
Behavioral Core Lab
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