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Peter M Morganelli, Ph.D.

Title(s):
Research Associate Professor of Microbiology and Immunology

Department(s):
Microbiology and Immunology

Education:
Dartmouth Medical School, Ph.D., 1988
Miami of Ohio, M.S., 1983
Clark University, B.S., 1979

Dr. Morganelli received his undergraduate degree from Clark University in 1979, a Master's degree from Miami of Ohio in 1983, and a Ph.D. from Dartmouth College in 1988. After post-doctoral work in the Department of Microbiology at Dartmouth Medical School, he joined the faculty in 1991.

Websites:
http://dms.dartmouth.edu/microbio/

http://dms.dartmouth.edu/immuno/

Contact Information:

VA Hospital Code 151
215 N. Main Street
White River Jct. VT 05009
Phone: 802-295-9363
Fax: 802-296-6308
Email: pmm@Dartmouth.edu

Assistant: Mary Griffin
Asst. Phone: 802-295-9363
Asst. Email: mary.griffin@dartmouth.edu


Selected Publications:

 

Drinane M, Mollmark J, Zagorchev L, Moodie K, Sun B, Hall A, Shipman S, Morganelli P, Simons M, Mulligan-Kehoe MJ
The antiangiogenic activity of rPAI-1(23) inhibits vasa vasorum and growth of atherosclerotic plaque.
Circ Res 2009 Feb 13; 104(3):337-45
PMID: 19122176 [PubMed - indexed for MEDLINE]

Wells WA, Schwartz GN, Morganelli PM, Cole BF, Gibson JJ, Kinlaw WB
Expression of "Spot 14" (THRSP) predicts disease free survival in invasive breast cancer: immunohistochemical analysis of a new molecular marker.
Breast Cancer Res Treat 2006 Jul; 98(2):231-40
PMID: 16552628 [PubMed - indexed for MEDLINE]

Martel PM, Bingham CM, McGraw CJ, Baker CL, Morganelli PM, Meng ML, Armstrong JM, Moncur JT, Kinlaw WB
S14 protein in breast cancer cells: direct evidence of regulation by SREBP-1c, superinduction with progestin, and effects on cell growth.
Exp Cell Res 2006 Feb 1; 312(3):278-88
PMID: 16300755 [PubMed - indexed for MEDLINE]

Sakashita N, Miyazaki A, Chang CC, Chang TY, Kiyota E, Satoh M, Komohara Y, Morganelli PM, Horiuchi S, Takeya M
Acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) is induced in monocyte-derived macrophages: in vivo and in vitro studies.
Lab Invest 2003 Nov; 83(11):1569-81
PMID: 14615411 [PubMed - indexed for MEDLINE]

Hintz KA, Rassias AJ, Wardwell K, Moss ML, Morganelli PM, Pioli PA, Givan AL, Wallace PK, Yeager MP, Guyre PM
Endotoxin induces rapid metalloproteinase-mediated shedding followed by up-regulation of the monocyte hemoglobin scavenger receptor CD163.
J Leukoc Biol 2002 Oct; 72(4):711-7
PMID: 12377940 [PubMed - indexed for MEDLINE]


Professional Interests:

Dr. Morganelli's laboratory is focused in general on the role of the immune system in the formation of atherosclerotic lesions, in particular the role of macrophage IgG Fc receptors. He is interested in understanding whether the metabolic uptake and processing of lipoprotein immune complexes is normally atherogenic or protective, and whether vaccine strategies are feasible for lowering the risk of heart disease in particular individuals. The approaches to these problems include functional studies of human mononuclear phagocytes in vitro and more recently the quantification of lesion formation in murine models.

Grant Information:

US Department of Veterans Affairs Merit Review- Fcgamma receptors and the formation of atherosclerotic lesions in vivo (2003-2008).

Copyright © 2009 Trustees of Dartmouth College

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