Dartmouth Medical School - Faculty Database

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Donald L. St. Germain, M.D.

Title(s):
Professor of Medicine and of Physiology

Department(s):
Medicine
Physiology

Education:
M.D., Johns Hopkins University School of Medicine

Programs:
Program in Experimental and Molecular Medicine

Contact Information:

One Medical Center Drive, HB 7700 Lebanon NH 03756
Office: Borwell 728W Phone: 603-650-7910 Fax: 603-650-6130 Email: stgermain@dartmouth.edu Assistant: Christin Kjelland Asst. Phone: 603-650-0813 Asst. Email: Christin.Kjelland@Dartmouth.edu

Selected Publications:

Schneider MJ, Fiering SN, Pallud SE, Parlow AF, St Germain DL, Galton VA. Targeted disruption of the type 2 selenodeiodinase gene (DIO2) results in a phenotype of pituitary resistance to T4. Mol Endocrinol. 2001 Dec;15(12):2137-48. (view details on MedLine)

Hernandez A, St Germain DL. Dexamethasone inhibits growth factor-induced type 3 deiodinase activity and mRNA expression in a cultured cell line derived from rat neonatal brown fat vascular-stromal cells. Endocrinology. 2002 Jul;143(7):2652-8. (view details on MedLine)

Hernandez A, St Germain DL. Activity and response to serum of the mammalian thyroid hormone deiodinase 3 gene promoter: identification of a conserved enhancer. Mol Cell Endocrinol. 2003 Aug 29;206(1-2):23-32. (view details on MedLine)

Hernandez A, Martinez ME, Croteau W, St Germain DL. Complex organization and structure of sense and antisense transcripts expressed from the DIO3 gene imprinted locus. Genomics. 2004 Mar;83(3):413-24. (view details on MedLine)

Ng L, Goodyear RJ, Woods CA, Schneider MJ, Diamond E, Richardson GP, Kelley MW, Germain DL, Galton VA, Forrest D. Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase. Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3474-9. Epub 2004 Mar 1. (view details on MedLine)

Schneider MJ, Fiering SN, Thai B, Wu SY, St Germain E, Parlow AF, St Germain DL, Galton VA. Targeted disruption of the type 1 selenodeiodinase gene (Dio1) results in marked changes in thyroid hormone economy in mice. Endocrinology. 2006 Jan;147(1):580-9. Epub 2005 Oct 13. (view details on MedLine)

Hernandez A, Martinez ME, Fiering S, Galton VA, St Germain D. Type 3 deiodinase is critical for the maturation and function of the thyroid axis. J Clin Invest. 2006 Feb;116(2):476-84. Epub 2006 Jan 12. (view details on MedLine)

Trivieri MG, Oudit GY, Sah R, Kerfant BG, Sun H, Gramolini AO, Pan Y, Wickenden AD, Croteau W, Morreale de Escobar G, Pekhletski R, St Germain D, Maclennan DH, Backx PH. Cardiac-specific elevations in thyroid hormone enhance contractility and prevent pressure overload-induced cardiac dysfunction. Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):6043-8. Epub 2006 Apr 4. (view details on MedLine)

Galton VA, Wood ET, St Germain EA, Withrow CA, Aldrich G, St Germain GM, Clark AS, St Germain DL. Thyroid hormone homeostasis and action in the type 2 deiodinase-deficient rodent brain during development. Endocrinology. 2007 Jul;148(7):3080-8. Epub 2007 Mar 1. (view details on MedLine)

Hernandez A, Martinez ME, Liao XH, Van Sande J, Refetoff S, Galton VA, St Germain DL. Type 3 deiodinase deficiency results in functional abnormalities at multiple levels of the thyroid axis. Endocrinology. 2007 Dec;148(12):5680-7. Epub 2007 Sep 6. (view details on MedLine)

Professional Interests:

Metabolism of thyroid hormones

Thyroid hormone action and metabolism in neural tissue and the anterior pituitary gland

Thyroid hormone action and metabolism during development

Selenoproteins

Courses Taught:

Courses Taught:
•Dartmouth Medical School Undergraduate Teaching:
Preceptor – 1st year On Doctoring Course
Lecturer/Discussion Leader - 1st year Endocrine Physiology Course
Lecturer/Discussion Leader - 2nd year Scientific Basis of Medicine Course, Endocrinology/Metabolism Section
Lecturer/Discussion Leader - Advanced Endocrine Physiology Course
Teaching Attending - 3rd year Basic Medicine Clerkship
Director - 4th year required Advanced Medical Sciences Course

•Dartmouth-Hitchcock Medical Center Residency and Continuing Education:
Attending Physician - Internal Medicine Service
Attending Physician - Endocrinology/Metabolism Consult Service
Attending Physician - Endocrinology/Metabolism Outpatient Clinics
Lecturer - Medical Housestaff Teaching Conferences
Course Director – Update in Endocrinology CME Course; 4/26/06, Manchester, NH
Program Director – DHMC Endocrinology/Metabolism Fellowship Program

•Dartmouth Medical School Pubic Education Program:
Director - Dartmouth Community Medical School public education initiative (1998 – present)

Grant Information:

Current Grant Support:

•NIH R01 Grant (#R0-1 DK-54716-1)
Title: The role of the type 3 deiodinase in development
Principal Investigator: Donald L. St. Germain
Current Period of Funding: 4/1/04 -3/31/09

•NIH NRSA Training Grant (#DK-07508)
Title: The role of hormones in health and disease
Co-Investigator: Donald L. St. Germain
Principal Investigator: William G. North
Current Period of Funding: 7/1/07-6/30/12

Submitted Grants:
• NIH R01 Application
Title: The role of the type 3 deiodinase in development
Role on project: Principal Investigator
• NIH R01 Application
Title: Impact of nutrition and illness on thyroid homeostasis
Role on project: Principal Investigator
• NIH R01 Application
Title: Pre-receptor Modulation of Thyroid Hormone Action in the Developing Brain
Role on project: Co-Investigator

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