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Eva M Rzucidlo, M.D.
Title(s):
Assistant Professor of Surgery (Vascular Surgery)
Department(s):
Surgery
Education:
1984 – 1988 B.A. with honors, Biological Chemistry, Wellesley College, Wellesley, Massachusetts,
1989 - 1993 MD Robert Wood Johnson Medical School, New Brunswick, New Jersey
Programs:
Program in Experimental and Molecular Medicine
Websites:
Contact Information:
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One Medical Center Drive, HB 7999 Dept of Vascular Surgery, 3V Reception Lebanon NH 03756 |
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Office: Borwell 530E Phone: 603-650-7604 Fax: 603-650-4973 Assistant: Barbara Decelle Asst. Phone: 603-650-8670 Asst. Email: barbara.decelle@hitchcock.org |
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Selected Publications: |
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Martin KA, Merenick BL, Ding M, Fetalvero KM, Rzucidlo EM, Kozul CD, Brown DJ, Chiu HY, Shyu M, Drapeau BL, Wagner RJ, Powell RJ. Rapamycin promotes vascular smooth muscle cell differentiation through insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt2 feedback signaling. J Biol Chem. 2007 Dec 7;282(49):36112-20. Epub 2007 Sep 30. (view details on MedLine) Powell RJ, Martin KA, Wagner R, Rzucidlo EM Statins induce VSMC differentiation through Rheb/mTOR pathway. Circ Res, in press 2008. Powell RJ, Martin KA, Wagner R, Powell RJ, Rzucidlo EM. Statins inhibit CTGF up-regulation by TGF-beta in VSMC through the AKT pathway. Am J Physiol. In press 2008. Rzucidlo EM, Martin KA, Powell RJ. Regulation of vascular smooth muscle cell differentiation. J Vasc Surg. 2007 Jun;45 Suppl A:A25-32. Review. (view details on MedLine) Rzucidlo EM, Wagner, R. mTOR localizes to the Golgi. J Vasc Surg. 2007. Brown DJ, Rzucidlo EM, Merenick BL, Wagner RJ, Martin KA, Powell RJ. Endothelial cell activation of the smooth muscle cell phosphoinositide 3-kinase/Akt pathway promotes differentiation. J Vasc Surg. 2005 Mar;41(3):509-16. (view details on MedLine) Martin KA, Rzucidlo EM, Merenick BL, Fingar DC, Brown DJ, Wagner RJ, Powell RJ. The mTOR/p70 S6K1 pathway regulates vascular smooth muscle cell differentiation. Am J Physiol Cell Physiol. 2004 Mar;286(3):C507-17. Epub 2003 Oct 30. (view details on MedLine) |
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Professional Interests:
1) Intimal hyperplasia and restenosis of stents is like a cancer of the arteries. Vascular smooth muscle cells are able to switch from a normal contractile phenotype to dedifferentiated vascular smooth muscle cell which migrates, proliferates, and secretes extracellular matrix protein in response to vessel injury. No cure for restenosis has yet to have been determined. Statins have been noted to have significant benefits for patients with cardiovascular disease, not just through its cholesterol lowering effect. We are investigating the effect that statins have on vascular smooth muscle differentiation in hopes to find a cure for intimal hyperplasia. We have found that the mTOR pathway is important to controlling the phenotypic modulation of VSMC. We are further attempting to decipher the signally pathway responsible for modulation the phenotypic modulation. This work has further expanded to the effects of statins on vascular smooth muscle cell differentiation, especially statins effect on the mTOR pathway.
2) Polymer-based drug eluting stents have drastically reduced restenosis. Issues related to potential tradeoffs between efficacy and safety has received increasing attention due to increased risk of late thrombosis. The cause for delayed healing has not been determined. We hypothesize that the stent polymers, not the eluting drugs, are the cause of delayed re-endothelialization. We have found that rapamycin inhibited EC migration is rescued by therapeutic doses of ticlopidine, aspirin or clopidogrel. Both polymer and biodegradable stent coatings inhibited EC adhesion and migration. Polymers which induce ECs migration should be developed to improve stent healing and therefore prevent the devastating effects of late stent thrombosis. We are now investigating different types of lipids and fatty acids that may be able to promote EC migration and therefore allow for better healing of stents.
Courses Taught:
PEMM Vascular Biology
Pharmocology Toxicology: Case Conferences
Grant Information:
Past:
1. Atorvastatin Research Award (Pfizer), Awarded 6/2005 (Projected period 6/1/2005-6/1/2006), Statin Effect on Vascular Smooth Muscle Cell Differentiation Through the mTOR pathway
Present:
1. KO8 HL076658-01, Awarded 6/1/2004 ( Project period 6/1/2004-5/31/2008), mTOR Regulation of VSMC Differentiation
2. Boston Scientific funded clinical project. : Randomized Controlled Study Comparing Treatment of Femoropopliteal disease with primary stenting and post angioplasty vs. primary stenting and post cryoplasty.
In Preparation:
1. R01, Submission date November, Statin regulation of vascular remodeling through small GTPase Rheb
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