Dartmouth Medical School - Faculty Database

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Michael E. Zegans, M.D.

Title(s):
Associate Professor of Surgery (Ophthalmology) and of Microbiology and Immunology

Department(s):
Microbiology and Immunology
Surgery

Education:
U. California - San Francisco School of Medicine, MD 1992
Wesleyan University, BA 1985

NIH Biosketch:
Zegans_M_BIO_2009-01-30.pdf

Websites:
http://www.dms.dartmouth.edu/microbio/faculty/

Contact Information:

Dartmouth Medical School HB 7999 Hanover NH 03755
Phone: 603-650-5123 Assistant: Megan Young Asst. Phone: 603-650-5123

Selected Publications:

Zegans ME, Sanchez PA, Likosky DS, Allar RT, Martin M, Schwartzman JD, Pryor JH, Turco JH, Whitney CG
Clinical features, outcomes, and costs of a conjunctivitis outbreak caused by the ST448 strain of Streptococcus pneumoniae.
Cornea 2009 Jun; 28(5):503-9
PMID: 19421049 [PubMed - indexed for MEDLINE]

Toutain-Kidd CM, Kadivar SC, Bramante CT, Bobin SA, Zegans ME
Polysorbate 80 inhibition of Pseudomonas aeruginosa biofilm formation and its cleavage by the secreted lipase LipA.
Antimicrob Agents Chemother 2009 Jan; 53(1):136-45
PMID: 18955535 [PubMed - indexed for MEDLINE]

Zegans ME, Wagner JC, Cady KC, Murphy DM, Hammond JH, O'Toole GA
Interaction between bacteriophage DMS3 and host CRISPR region inhibits group behaviors of Pseudomonas aeruginosa.
J Bacteriol 2009 Jan; 191(1):210-9
PMID: 18952788 [PubMed - indexed for MEDLINE]

Kirn TJ, Levy NB, Gosselin JJ, Rosen WJ, Zegans ME
Peripheral T-cell lymphoma presenting as sclerouveitis.
Cornea 2007 Oct; 26(9):1147-9
PMID: 17893556 [PubMed - indexed for MEDLINE]

Bramante CT, Talbot EA, Rathinam SR, Stevens R, Zegans ME
Diagnosis of ocular tuberculosis: a role for new testing modalities?
Int Ophthalmol Clin 2007 Summer; 47(3):45-62
PMID: 17667275 [PubMed - indexed for MEDLINE]

Toutain CM, Caizza NC, Zegans ME, O'Toole GA
Roles for flagellar stators in biofilm formation by Pseudomonas aeruginosa.
Res Microbiol 2007 Jun; 158(5):471-7
PMID: 17533122 [PubMed - indexed for MEDLINE]

Zegans ME, Shanks RM, O'Toole GA
Bacterial biofilms and ocular infections.
Ocul Surf 2005 Apr; 3(2):73-80
PMID: 17131010 [PubMed]

Shanks RM, Donegan NP, Graber ML, Buckingham SE, Zegans ME, Cheung AL, O'Toole GA
Heparin stimulates Staphylococcus aureus biofilm formation.
Infect Immun 2005 Aug; 73(8):4596-606
PMID: 16040971 [PubMed - indexed for MEDLINE]

Toutain CM, Zegans ME, O'Toole GA
Evidence for two flagellar stators and their role in the motility of Pseudomonas aeruginosa.
J Bacteriol 2005 Jan; 187(2):771-7
PMID: 15629949 [PubMed - indexed for MEDLINE]

Becker HI, Walton RC, Diamant JI, Zegans ME
Anterior uveitis and concurrent allergic conjunctivitis associated with long-term use of topical 0.2% brimonidine tartrate.
Arch Ophthalmol 2004 Jul; 122(7):1063-6
PMID: 15249377 [PubMed - indexed for MEDLINE]

Professional Interests:

Clinical: Diseases of the cornea, ocular surface and uveitis

Surgical: Corneal transplantation, cataract surgery, conjunctival tumors

Research: Ocular microbiology and bacterial biofilm formation

Courses Taught:

Decoding the Uveitis Workup, American Academy of Ophthalmology Instructional Course. 2001-2009

Grant Information:

NEI: 5K08EY013977-05

5 year grant to study bacterial biofilm formation in eye infections involving pseudomonas aeruginosa

Steroids for Corneal Ulcer Trial (SCUT)

NEI funded trial of the role of topical steroids in the treatment of bacterial corneal ulceration. The study is a collaboration between the Proctor Foundation at UCSF, Dartmouth and Aravind Eye Hospital in Tamil Nadu, India.

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