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Aniko Naray-Fejes-Toth, M.D.
Title(s):
Professor of Physiology
Department(s):
Physiology
Education:
Semmelweis University, M.D. 1973
Programs:
Program in Experimental and Molecular Medicine
Contact Information:
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One Medical Center Drive, HB 7700 Lebanon NH 03756 |
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Office: Borwell 736W Phone: 603-650-2581 Email: Aniko.Fejes-Toth@dartmouth.edu Assistant: Rhonda Stewart Asst. Phone: 603-650-6132 Asst. Email: Rhonda.A.Stewart@dartmouth.edu |
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Selected Publications: |
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Pearce D, Náray-Fejes-Tóth A, Fejes-Tóth G. Determinants of subnuclear organization of mineralocorticoid receptor characterized through analysis of wild type and mutant receptors. J Biol Chem. 2002 Jan 11;277(2):1451-6. Epub 2001 Oct 24. (view details on MedLine) Helms MN, Fejes-Tóth G, Náray-Fejes-Tóth A. Hormone-regulated transepithelial Na+ transport in mammalian CCD cells requires SGK1 expression. Am J Physiol Renal Physiol. 2003 Mar;284(3):F480-7. Epub 2002 Nov 12. (view details on MedLine) Náray-Fejes-Tóth A, Snyder PM, Fejes-Tóth G. The kidney-specific WNK1 isoform is induced by aldosterone and stimulates epithelial sodium channel-mediated Na+ transport. Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17434-9. Epub 2004 Dec 6. (view details on MedLine) Boyd C, Náray-Fejes-Tóth A. Gene regulation of ENaC subunits by serum- and glucocorticoid-inducible kinase-1. Am J Physiol Renal Physiol. 2005 Mar;288(3):F505-12. Epub 2004 Nov 9. (view details on MedLine) Náray-Fejes-Tóth A, Fejes-Tóth G. Novel mouse strain with Cre recombinase in 11beta-hydroxysteroid dehydrogenase-2-expressing cells. Am J Physiol Renal Physiol. 2007 Jan;292(1):F486-94. Epub 2006 Aug 8. (view details on MedLine) Fejes-Tóth G, Náray-Fejes-Tóth A. Early aldosterone-regulated genes in cardiomyocytes: clues to cardiac remodeling? Endocrinology. 2007 Apr;148(4):1502-10. Epub 2007 Jan 18. (view details on MedLine) Cordas E, Náray-Fejes-Tóth A, Fejes-Tóth G. Subcellular location of serum- and glucocorticoid-induced kinase-1 in renal and mammary epithelial cells. Am J Physiol Cell Physiol. 2007 May;292(5):C1971-81. Epub 2007 Jan 3. (view details on MedLine) Boyd C, Náray-Fejes-Tóth A. Steroid-mediated regulation of the epithelial sodium channel subunits in mammary epithelial cells. Endocrinology. 2007 Aug;148(8):3958-67. Epub 2007 May 17. (view details on MedLine) Martel JA, Michael D, Fejes-Tóth G, Náray-Fejes-Tóth A. Melanophilin, a novel aldosterone-induced gene in mouse cortical collecting duct cells. Am J Physiol Renal Physiol. 2007 Sep;293(3):F904-13. Epub 2007 Jul 3. (view details on MedLine) Fejes-Toth G, Frindt G, Naray-Fejes-Toth A, Palmer LG. Epithelial Na+ channel activation and processing in mice lacking SGK1. Am J Physiol Renal Physiol. 2008 Apr 2. [Epub ahead of print] (view details on MedLine) |
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Professional Interests:
The major research interest of Dr. Naray-Fejes-Toth is the cellular and molecular mechanisms by which steroid hormones regulate kidney function and blood pressure. One project in her laboratory focuses on the elucidation of mechanisms that confer aldosterone-selectivity to mineralocorticoid target tissues. This study is based on the observation that the mineralocorticoid apparently cannot distinguish between aldosterone and endogenous glucocorticoids, the blood levels of which are ~1000-fold higher than those of aldosterone. Aldosterone-selectivity in target cells is conferred by an enzyme, 11ß-hydroxysteroid dehydrogenase, which metabolizes glucocorticoids to a biologically inactive form, and thereby allows aldosterone to occupy its receptor. Dr. Naray-Fejes-Toth's laboratory discovered a new form of this enzyme, which is specifically present in aldosterone-target cells. The laboratory cloned the cDNA of this novel enzyme and currently examines its intracellular localization and the regulation of its cell-specific expression. Recent studies proved that mutations in the gene of this enzyme causes a fatal disease in children, called apparent mineralocorticoid excess.
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