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James C. Leiter, M.D.
Title(s):
Professor of Physiology and of Medicine
Department(s):
Medicine
Physiology
Education:
Dartmouth College, AB 1975
Dartmouth Medical School, MD 1979
Programs:
Neuroscience Center at Dartmouth
Program in Experimental and Molecular Medicine
Websites:
http://dms.dartmouth.edu/ncd/
Contact Information:
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Dartmouth Medical School HB 7700 Hanover NH 03755 |
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Office: Borwell 734E Phone: 603-650-8533 Fax: 603-650-6130 Email: James.C.Leiter@Dartmouth.EDU Assistant: Mary Durand Asst. Phone: 603-650-7717 Asst. Email: Mary.L.Durand@Dartmouth.EDU |
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Selected Publications: |
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Manning HL, Leiter JC. Respiratory control and respiratory sensation in a patient with a ganglioma within the dorsocaudal brain stem. Am J Respir Crit Care Med. 2000 Jun;161(6):2100-6. (view details on MedLine) Ritucci NA, Erlichman JS, Leiter JC, Putnam RW. Response of membrane potential and intracellular pH to hypercapnia in neurons and astrocytes from rat retrotrapezoid nucleus. Am J Physiol Regul Integr Comp Physiol. 2005 Sep;289(3):R851-61. Epub 2005 May 19. (view details on MedLine) Lee KH, Blaha CD, Harris BT, Cooper S, Hitti FL, Leiter JC, Roberts DW, Kim U. Dopamine efflux in the rat striatum evoked by electrical stimulation of the subthalamic nucleus: potential mechanism of action in Parkinson's disease. Eur J Neurosci. 2006 Feb;23(4):1005-14. (view details on MedLine) Denton JS, McCann FV, Leiter JC. CO2 chemosensitivity in Helix aspersa: three potassium currents mediate pH-sensitive neuronal spike timing. Am J Physiol Cell Physiol. 2007 Jan;292(1):C292-304. Epub 2006 Aug 23. (view details on MedLine) Chernov MM, Daubenspeck JA, Denton JS, Pfeiffer JR, Putnam RW, Leiter JC. A computational analysis of central CO2 chemosensitivity in Helix aspersa. Am J Physiol Cell Physiol. 2007 Jan;292(1):C278-91. Epub 2006 Aug 23. (view details on MedLine) Lee KH, Kristic K, van Hoff R, Hitti FL, Blaha C, Harris B, Roberts DW, Leiter JC. High-frequency stimulation of the subthalamic nucleus increases glutamate in the subthalamic nucleus of rats as demonstrated by in vivo enzyme-linked glutamate sensor. Brain Res. 2007 Aug 8;1162:121-9. Epub 2007 Jun 21. (view details on MedLine) Leiter JC, Böhm I. Mechanisms of pathogenesis in the Sudden Infant Death Syndrome. Respir Physiol Neurobiol. 2007 Nov 15;159(2):127-38. Epub 2007 Jun 8. Review. (view details on MedLine) Xia L, Damon T, Niblock MM, Bartlett D Jr, Leiter JC. Unilateral microdialysis of gabazine in the dorsal medulla reverses thermal prolongation of the laryngeal chemoreflex in decerebrate piglets. J Appl Physiol. 2007 Nov;103(5):1864-72. Epub 2007 Sep 6. (view details on MedLine) St-John WM, Leiter JC. Maintenance of gasping and restoration of eupnea after hypoxia is impaired following blockers of alpha1-adrenergic receptors and serotonin 5-HT2 receptors. J Appl Physiol. 2008 Mar;104(3):665-73. Epub 2007 Dec 27. (view details on MedLine) Erlichman JS, Hewitt A, Damon TL, Hart M, Kurascz J, Li A, Leiter JC. Inhibition of monocarboxylate transporter 2 in the retrotrapezoid nucleus in rats: a test of the astrocyte-neuron lactate-shuttle hypothesis. J Neurosci. 2008 May 7;28(19):4888-96. (view details on MedLine) |
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Professional Interests:
Dr. Leiter is interested in the neurophysiology of respiratory control, central chemosensitivity and Sudden Infant Death Syndrome. He is interested in the role of astrocytes in all of these topics. Additional interests include the neurobiology of deep brain stimulation in Parkinson’s Disease and psychiatric disorders.
Courses Taught:
Medical Physiology (Cardiac and Respiratory sections); Advanced Respiratory Physiology
Grant Information:
Grant Information:
NIH NICHD. RO1 HD042707-01. The upper airway and the Sudden Infant Death Syndrome. (co-investigator with Donald Bartlett, Jr.).
NIH NICHD. Program Project Grant: The ventral medulla and the sudden infant death syndrome. Project II: The medullary serotonergic system and respiratory control in the unanesthetized piglet. (co-investigator with H. Kinney.).
Flight Attendants Medical Research Institute. Second-hand smoke and SIDS: a laryngeal connection? (co-investigator. with Dr. Bartlett).
Johnson and Johnson COSAT program. Development of closed-loop 'smart' deep brain stimulation. (Leiter, P.I.).
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