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Paul M. Guyre, Ph.D.
Title(s):
Professor of Physiology, and of Microbiology and Immunology
Department(s):
Microbiology and Immunology
Physiology
Education:
Montclair State College, BA 1972
U. New Hampshire, PHD 1979
U. New Hampshire, MS 1976
Programs:
Immunology Program
Molecular and Cellular Biology Graduate Programs
Norris Cotton Cancer Center
Program in Experimental and Molecular Medicine
NIH Biosketch:
Guyre_P_BIO_2009-02-09.pdf
Websites:
http://dms.dartmouth.edu/COBRE/
http://dms.dartmouth.edu/immuno/
http://dms.dartmouth.edu/microbio/
Contact Information:
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Dartmouth Medical School HB 7700 Hanover NH 03755 |
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Office: Borwell 740W Phone: 603 650-7924 Fax: 603 650-6130 Email: paul.guyre@dartmouth.edu |
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Selected Publications: |
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Yeager MP, Rassias AJ, Pioli PA, Beach ML, Wardwell K, Collins JE, Lee HK, Guyre PM |
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Professional Interests:
Dr. Guyre's principal research interest is understanding how hormones and cytokines regulate the functional activity of white blood cells including monocytes, macrophages, dendritic cells, and neutrophils. The goal of Dr. Guyre's current research is to elucidate the physiologic interactions between steroid hormones that often regulate immune responses and molecules that activate the immune system such as cytokines and interferons. For example, bacterial infections stimulate the production of cytokines that activate leukocytes, but also feed back via the brain and pituitary to stimulate the release of cortisol from the adrenal gland. Cortisol (as well as related steroids that are used therapeutically as anti-inflammatory agents) then interacts with cytokines to either enhance or inhibit leukocyte activation as needed. Together with collaborators Drs. Wira, Yeager, Morganelli and Fanger, Dr. Guyre's research team is identifying the mechanisms by which leukocyte receptors and signaling pathways are regulated by hormones and cytokines to enhance the killing of pathogens and/or suppress inflammation in sepsis, autoimmunity and cardiovascular disease.
Courses Taught:
DMSI Physiology
DMSI Immunology
Advanced Endocrinology
Advanced Biomedical Sciences
Grant Information:
NIH
Copyright © 2009 Trustees of Dartmouth College