de Agostini AI, Dong J-C, de Vantéry-Arrighi C, Ramus M-A, Dentand-Quadri I, Thalmann S, Ventura P, Ibecheole V, Monge F, Fischer A-M, HajMohammadi S, Shworak NW, Zhang L, Zhang Z, Linhardt RJ. Human follicular fluid heparan sulfate contains abundant 3-O-sufated chains with anticoagulant activity. J Biol Chem 2008, 283: in press
Isaev D, Isaeva E, Shatskih T, Zhao Q, Smits NC, Shworak NW, Khazipov R, Holmes GL. Role of extracellular sialic acid in regulation of neuronal and network excitability in the rat hippocampus. J Neurosci. 2007 Oct 24;27(43):11587-94. (view details on MedLine)
Lawrence R, Yabe T, Hajmohammadi S, Rhodes J, McNeely M, Liu J, Lamperti ED, Toselli PA, Lech M, Spear PG, Rosenberg RD, Shworak NW. The principal neuronal gD-type 3-O-sulfotransferases and their products in central and peripheral nervous system tissues. Matrix Biol. 2007 Jul;26(6):442-55. Epub 2007 Mar 30. (view details on MedLine)
Girardin EP, Hajmohammadi S, Birmele B, Helisch A, Shworak NW, de Agostini AI. Synthesis of anticoagulantly active heparan sulfate proteoglycans by glomerular epithelial cells involves multiple 3-O-sulfotransferase isoforms and a limiting precursor pool. J Biol Chem. 2005 Nov 11;280(45):38059-70. Epub 2005 Aug 17. (view details on MedLine)
Shworak NW. Angiogenic modulators in valve development and disease: does valvular disease recapitulate developmental signaling pathways? Curr Opin Cardiol. 2004 Mar;19(2):140-6. Review. (view details on MedLine)
Kamimura K, Rhodes JM, Ueda R, McNeely M, Shukla D, Kimata K, Spear PG, Shworak NW, Nakato H. Regulation of Notch signaling by Drosophila heparan sulfate 3-O sulfotransferase. J Cell Biol. 2004 Sep 27;166(7):1069-79. (view details on MedLine)
HajMohammadi S, Enjyoji K, Princivalle M, Christi P, Lech M, Beeler D, Rayburn H, Schwartz JJ, Barzegar S, de Agostini AI, Post MJ, Rosenberg RD, Shworak NW Normal levels of anticoagulant heparan sulfate are not essential for normal hemostasis. J Clin Invest. 2003 Apr;111(7):989-99. (view details on MedLine)
Yabe T, Shukla D, Spear PG, Rosenberg RD, Seeberger PH, Shworak NW. Portable sulphotransferase domain determines sequence specificity of heparan sulphate 3-O-sulphotransferases. Biochem J. 2001 Oct 1;359(Pt 1):235-41. (view details on MedLine)
Shukla D, Liu J, Blaiklock P, Shworak NW, Bai X, Esko JD, Cohen GH, Eisenberg RJ, Rosenberg RD, Spear PG. A novel role for 3-O-sulfated heparan sulfate in herpes simplex virus 1 entry. Cell. 1999 Oct 1;99(1):13-22. (view details on MedLine)
Shworak NW, Liu J, Petros LM, Zhang L, Kobayashi M, Copeland NG, Jenkins NA, Rosenberg RD. Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci. J Biol Chem. 1999 Feb 19;274(8):5170-84. (view details on MedLine)
Professional Interests:
Role of heparan sulfate (HS) in normal and diseased states of the cardiovascular and nervous systems. Role of 3-O-sulfated HS motifs in myxomatous valvular disease, anti-inflammitory vascular tone, antithrombin signaling, Notch signaling, herpes virus infectivity, and animal behavior.
Courses Taught:
Introduction to Molecular Biology for Cardiologists.
Vasculata 2005: “Imaging molecular events” and “Drosophila Genetic Models of angiogenesis”
PEMM 101/102
Grant Information:
NIH:
3-OST-1 Deficiency and Cardiovascular Disease
3-OST-1 Regulation of Antithrombin Isoform Partitioning
A Vevo 770 for Ultrasound Biomicroscopy