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Mary Jo Mulligan-Kehoe, Ph.D.
Title(s):
Associate Professor of Surgery
Department(s):
Surgery
Education:
Education
B.S. Biology, Northern Michigan University
M.S. Molecular Biology, George Mason University
Ph.D. Biochemistry, Catholic University of Louvain
Post-Doctoral Training
1990-1994 Postdoctoral Fellow, NCI/NIH
1994-1998 Senior Staff Fellow NCI/NIH
Academic Appointments
1994-1998 Affiliate Professor of Biology, George Mason University
1998-2006 Research Assistant Professor, Department of Surgery/Vascular, Dartmouth Medical School
2006-present Research Associate Professor, Department of Surgery/Vascular, Dartmouth Medical School
Programs:
Angiogenesis Research Center
Norris Cotton Cancer Center
Program in Experimental and Molecular Medicine
Websites:
http://www.dartmouth.edu/~angio/
http://www.cancer.dartmouth.edu/research/mechanisms/index.shtml
http://www.dhmc.org/webpage.cfm?site_id=2&org_id=129&gsec_id=0&sec_id=0&item_id=3510
Contact Information:
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Dartmouth Medical School Borwell 530E, 1 Medical Center Drive Lebanon, NH 03756 Lebanon NH 03756 |
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Office: Borwell 530E Phone: 603-650-8597 Email: mary.j.mulligan-kehoe@dartmouth.edu Asst. Phone: Laboratory 603-650-7614 |
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Selected Publications: |
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Mulligan-Kehoe MJ, Wagner R, Wieland C, Powell R. A truncated plasminogen activator inhibitor-1 protein inhibits angiostatin (K1-3), a plasminogen cleavage product. J. Biol. Chem. 276(11):8588-8596, 2001. (view details on MedLine) Mulligan-Kehoe MJ, Kleinman HK, Drinane M, Wieland C, Wagner RJ, Powell RJ A truncated plasminogen activator inhibitor-1 protein blocks the availability of heparin-binding VEGF-A isoforms. J. Biol. Chem. 277(50): 49077-49089, 2002 (view details on MedLine) Drinane MC, Sherman JA, Hall AE, Simons M, Mulligan-Kehoe MJ. Plasminogen and plasmin activity in patients with coronary artery disease. J. Thromb. Haem. 4: 1288-1295, 2006. (view details on MedLine) Drinane M, Walsh J, Mollmark J, Simons M, Mulligan-Kehoe MJ The anti-angiogenic activity of rPAI-1 23 inhibits fibroblast growth factor-2 functions. J. Biol. Chem. 281:33336-33344, 2006 (view details on MedLine) Mulligan-Kehoe MJ, Drinane MC, Mollmark J, Casciola-Rosen L, Hummers LK, Hall A, Rosen A, Wiigley FM, Simons M Antiangiogenic plasma activity in patients with systemic sclerosis. Arthritis Rheum. 56: 3448-58, 2007 (view details on MedLine) Drinane M, Mollmark J, Zagorchev L, Moodie K, Sun B, Hall A, Shipman S, Morganelli P, Simons M, Mulligan-Kehoe MJ The Antiangiogenic Activity of rPAI-123 Inhibits Vasa Vasorum and Growth of Atherosclerotic Plaque. Circ Res. 2009 Feb 13;104(3):337-45 (view details on MedLine) |
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Professional Interests:
The research focus in Dr. Mulligan-Kehoe’s laboratory is anti-angiogenesis. In vitro and ex vivo studies include:
- Identification of the signaling pathways that are activated in response to the activity of an anti-angiogenic recombinant truncated PAI-1 protein, rPAI-123, developed in Dr. Mulligan-Kehoe’s laboratory.
Investigating the mechanisms by which rPAI-123 inhibits angiogenesis associated with atherosclerotic plaque development in a mouse model of atherogenesis. Our current studies suggest that rPAI-123 promotes vessel regression accompanied by plaque regression.
-Development of systems for delivery of therapeutics to sites of neo-angiogenesis. This work will use endothelial precursor cells as vehicles for delivery of the anti-angiogenic rPAI-123 protein to sites of neo-angiogenesis in breast and brain tumors. These studies include microCT and microPET imaging of rPAI-123 inhibition of blood vessels that support tumor growth.
-Translational studies examine the anti-angiogenic factors found in plasma from scleroderma patients. Our recent findings show that these factors contribute to the vascular component of the disease.
Courses Taught:
PEMM 101-102
PEMM 275 (vascular biology)
Grant Information:
Current Funding
-Principal Investigator, R01 NIH/NHLBI
-Principal Investigator, Phillips Imaging Foundation Award
-Co-Investigator, SCCOR NIH/NHLBI
Copyright © 2009 Trustees of Dartmouth College