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Lloyd H. Kasper, M.D.

Title(s):
Professor of Medicine (Neurology), and of Microbiology and Immunology

Department(s):
Medicine
Microbiology and Immunology

Education:
Rush Medical College, MD 1975
University of Illinois, MS 1973
University of Illinois, BS 1970
University of Illinois, BA 1970
Dartmouth College MA (honorary) 1994

Lloyd Kasper received his undergraduate degrees in Rhetoric and Zoology from the University of Illinois, Urbana. After completing medical school in Chicago, he received clinical training in Internal Medicine and Neurology. He was appointed to the Dartmouth Medical School faculty in 1981. In addition to his research responsibilities, he is the Director of the Dartmouth-Hitchcock Multiple Sclerosis Clinic.

Programs:
Molecular and Cellular Biology Graduate Programs
Neuroscience Center at Dartmouth

Websites:
http://dms.dartmouth.edu/microbio/
http://dms.dartmouth.edu/ncd/

Contact Information:

Dartmouth Medical School
Rubin Bldg 701 HB 7556
1 Medical Center Drive
Lebanon NH 03756
Phone: 603-653-9909
Fax: 603-653-9947
Email: Lloyd.H.Kasper@Dartmouth.EDU

Assistant: mary r. smith
Asst. Phone: 603 653 9948
Asst. Email: mary r. smith@hitchcock.org


Selected Publications:

 

Ochoa-Reparaz J, Mielcarz DW, Ditrio LE, Burroughs AR, Foureau DM, Haque-Begum S, Kasper LH
Role of gut commensal microflora in the development of experimental autoimmune encephalomyelitis.
J Immunol 2009 Nov 15; 183(10):6041-50
PMID: 19841183 [PubMed - in process]

Begum-Haque S, Haque A, Kasper LH
Apoptosis in Toxoplasma gondii activated T cells: the role of IFNgamma in enhanced alteration of Bcl-2 expression and mitochondrial membrane potential.
Microb Pathog 2009 Nov; 47(5):281-8
PMID: 19748565 [PubMed - in process]

Nowak EC, Weaver CT, Turner H, Begum-Haque S, Becher B, Schreiner B, Coyle AJ, Kasper LH, Noelle RJ
IL-9 as a mediator of Th17-driven inflammatory disease.
J Exp Med 2009 Aug 3; 206(8):1653-60
PMID: 19596803 [PubMed - indexed for MEDLINE]

Begum-Haque S, Sharma A, Kasper IR, Foureau DM, Mielcarz DW, Haque A, Kasper LH
Downregulation of IL-17 and IL-6 in the central nervous system by glatiramer acetate in experimental autoimmune encephalomyelitis.
J Neuroimmunol 2008 Nov 15; 204(1-2):58-65
PMID: 18804287 [PubMed - indexed for MEDLINE]

Haque A, Hober D, Kasper LH
Confronting potential influenza A (H5N1) pandemic with better vaccines.
Emerg Infect Dis 2007 Oct; 13(10):1512-8
PMID: 18258000 [PubMed - indexed for MEDLINE]

Menard LC, Minns LA, Darche S, Mielcarz DW, Foureau DM, Roos D, Dzierszinski F, Kasper LH, Buzoni-Gatel D
B cells amplify IFN-gamma production by T cells via a TNF-alpha-mediated mechanism.
J Immunol 2007 Oct 1; 179(7):4857-66
PMID: 17878385 [PubMed - indexed for MEDLINE]

Kasper LH, Everitt D, Leist TP, Ryan KA, Mascelli MA, Johnson K, Raychaudhuri A, Vollmer T
A phase I trial of an interleukin-12/23 monoclonal antibody in relapsing multiple sclerosis.
Curr Med Res Opin 2006 Sep; 22(9):1671-8
PMID: 16968570 [PubMed - indexed for MEDLINE]

Minns LA, Menard LC, Foureau DM, Darche S, Ronet C, Mielcarz DW, Buzoni-Gatel D, Kasper LH
TLR9 is required for the gut-associated lymphoid tissue response following oral infection of Toxoplasma gondii.
J Immunol 2006 Jun 15; 176(12):7589-97
PMID: 16751405 [PubMed - indexed for MEDLINE]

Lu F, Huang S, Hu MS, Kasper LH
Experimental ocular toxoplasmosis in genetically susceptible and resistant mice.
Infect Immun 2005 Aug; 73(8):5160-5
PMID: 16041033 [PubMed - indexed for MEDLINE]

Randolph JJ, Wishart HA, Saykin AJ, McDonald BC, Schuschu KR, MacDonald JW, Mamourian AC, Fadul CE, Ryan KA, Kasper LH
FLAIR lesion volume in multiple sclerosis: relation to processing speed and verbal memory.
J Int Neuropsychol Soc 2005 Mar; 11(2):205-9
PMID: 15962708 [PubMed - indexed for MEDLINE]


Professional Interests:

The research focus of this laboratory is on the immune response to and cell biology of Toxoplasma gondii. This parasite which is perhaps the most common parasitic infection of humans causes congenital disease in the newborn and is a major opportunistic infection in those with AIDS. Our research effort has been directed at understanding the interaction between the parasite and its host. Toxoplasma is able to stimulate both a host protective response and downregulate the immune system in order to survive. Our long term effort is to understand the mechanims of innate immunity to this opportunistic pathogen and how the host protects itself against recurrent chronic infection.

The second major area of interest is understanding the process of attachment, parasite replication and egress from the infected host cell. A variety of immunologic and molecular approaches are utilized to decipher these events during invasion and internalization.

Copyright © 2009 Trustees of Dartmouth College

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