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Michael W. Fanger, Ph.D.

Title(s):
Professor of Microbiology and Immunology, and of Medicine

Department(s):
Medicine
Microbiology and Immunology

Education:
Yale University, Ph.D., 1967

Wabash College, B.A., 1962

Professor Fanger received the B.A. degree from Wabash College in 1962 and the Ph.D. in Biochemistry from Yale University in 1967. After postdoctoral training at the National Institute for Medical Research in London, England and the University of Illinois Medical School in Chicago, he was appointed to the faculty of the Microbiology Department at Case Western Reserve University in Cleveland in 1970. In 1981, Professor Fanger moved to the Dartmouth Medical School. He served as Chair of the Department of Microbiology and Immunology from 1992 to 2002, and is currently Professor of Microbiology and Immunology, and Professor of Medicine.

Programs:
Immunology Program

Websites:
http://dms.dartmouth.edu/microbio/
http://dms.dartmouth.edu/immuno/
http://www.dartmouth.edu/~mcb/
http://dms.dartmouth.edu/COBRE/

Contact Information:

Dartmouth Medical School
Borwell Research Building-HB 7556
1 Medical Center Drive
Lebanon NH 03756
Office: Borwell 600W
Phone: 603-650-7505
Fax: 603-650-6223
Email: Michael.W.Fanger@Dartmouth.EDU


Selected Publications:

 

Smith JM, Shen Z, Wira CR, Fanger MW, Shen L
Effects of menstrual cycle status and gender on human neutrophil phenotype.
Am J Reprod Immunol 2007 Aug; 58(2):111-9
PMID: 17631004 [PubMed - indexed for MEDLINE]

Smith JM, Wira CR, Fanger MW, Shen L
Human fallopian tube neutrophils--a distinct phenotype from blood neutrophils.
Am J Reprod Immunol 2006 Oct; 56(4):218-29
PMID: 16938110 [PubMed - indexed for MEDLINE]

Shen L, Smith JM, Shen Z, Hussey SB, Wira CR, Fanger MW
Differential regulation of neutrophil chemotaxis to IL-8 and fMLP by GM-CSF: lack of direct effect of oestradiol.
Immunology 2006 Feb; 117(2):205-12
PMID: 16423056 [PubMed - indexed for MEDLINE]

Yeaman GR, Asin S, Weldon S, Demian DJ, Collins JE, Gonzalez JL, Wira CR, Fanger MW, Howell AL
Chemokine receptor expression in the human ectocervix: implications for infection by the human immunodeficiency virus-type I.
Immunology 2004 Dec; 113(4):524-33
PMID: 15554931 [PubMed - indexed for MEDLINE]

Shen L, Fahey JV, Hussey SB, Asin SN, Wira CR, Fanger MW
Synergy between IL-8 and GM-CSF in reproductive tract epithelial cell secretions promotes enhanced neutrophil chemotaxis.
Cell Immunol 2004 Jul; 230(1):23-32
PMID: 15541716 [PubMed - indexed for MEDLINE]

Asin SN, Fanger MW, Wildt-Perinic D, Ware PL, Wira CR, Howell AL
Transmission of HIV-1 by primary human uterine epithelial cells and stromal fibroblasts.
J Infect Dis 2004 Jul 15; 190(2):236-45
PMID: 15216456 [PubMed - indexed for MEDLINE]

Abrahams VM, Collins JE, Wira CR, Fanger MW, Yeaman GR
Inhibition of human polymorphonuclear cell oxidative burst by 17-beta-estradiol and 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Am J Reprod Immunol 2003 Dec; 50(6):463-72
PMID: 14750553 [PubMed - indexed for MEDLINE]

Asin SN, Wildt-Perinic D, Mason SI, Howell AL, Wira CR, Fanger MW
Human immunodeficiency virus type 1 infection of human uterine epithelial cells: viral shedding and cell contact-mediated infectivity.
J Infect Dis 2003 May 15; 187(10):1522-33
PMID: 12721932 [PubMed - indexed for MEDLINE]


Professional Interests:

Research in Dr. Fanger's laboratory has focused on studies of the role that innate immunity plays in inducing adaptive immunity in the human female reproductive tract and on the mechanisms by which antigen presentation is mediated by human Dendritic Cells (DCs). As DCs play a major role in the initiation of immunity through processing and presentation of antigen, fusion proteins that target antigens to molecules expressed primarily on antigen presenting cells are being investigated as vaccines for immunotherapy of cancer.

Courses Taught:

Biology 42

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