Dartmouth Medical School - Faculty Database

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Steven N. Fiering, Ph.D.

Title(s):
Associate Professor of Microbiology and Immunology, and of Genetics

Department(s):
Genetics
Microbiology and Immunology

Education:
Stanford, Ph.D., 1990
University of Michigan, BS, 1975

Dr. Fiering received his Bachelor of Science from the University of Michigan in 1975, and his Doctorate from Stanford in 1990. After postdoctoral work as an NIH research fellow and research associate at the Fred Hutchinson Cancer Research Center, Dr. Fiering joined the faculty of the Department of Microbiology at Dartmouth Medical School in 1997.

Programs:
Immunology Program
Molecular and Cellular Biology Graduate Programs
Norris Cotton Cancer Center

NIH Biosketch:
Fiering_S_BIO_2009-02-12.pdf

Websites:
http://dms.dartmouth.edu/microbio/
http://dms.dartmouth.edu/immuno/
http://www.dartmouth.edu/~mcb/
http://dms.dartmouth.edu/COBRE/

Contact Information:

Dartmouth Medical School Rubin Bldg. HB 7936 1 Medical Center Drive Lebanon NH 03756
Phone: 603-653-9966 Fax: 603-653-9952 Email: Steven.N.Fiering@Dartmouth.EDU

Selected Publications:

Coon CI, Fiering S, Gaudet J, Wyatt CA, Brinckerhoff CE
Site controlled transgenic mice validating increased expression from human matrix metalloproteinase (MMP-1) promoter due to a naturally occurring SNP.
Matrix Biol 2009 Sep; 28(7):425-31
PMID: 19577645 [PubMed - in process]

Hsu M, Richardson CA, Olivier E, Qiu C, Bouhassira EE, Lowrey CH, Fiering S
Complex developmental patterns of histone modifications associated with the human beta-globin switch in primary cells.
Exp Hematol 2009 Jul; 37(7):799-806.e4
PMID: 19460472 [PubMed - indexed for MEDLINE]

Lathrop MJ, Hsu M, Richardson CA, Olivier EN, Qiu C, Bouhassira EE, Fiering S, Lowrey CH
Developmentally regulated extended domains of DNA hypomethylation encompass highly transcribed genes of the human beta-globin locus.
Exp Hematol 2009 Jul; 37(7):807-813.e2
PMID: 19460471 [PubMed - indexed for MEDLINE]

Liu X, Sempere LF, Galimberti F, Freemantle SJ, Black C, Dragnev KH, Ma Y, Fiering S, Memoli V, Li H, DiRenzo J, Korc M, Cole CN, Bak M, Kauppinen S, Dmitrovsky E
Uncovering growth-suppressive MicroRNAs in lung cancer.
Clin Cancer Res 2009 Feb 15; 15(4):1177-83
PMID: 19228723 [PubMed - indexed for MEDLINE]

Mabaera R, Richardson CA, Johnson K, Hsu M, Fiering S, Lowrey CH
Developmental- and differentiation-specific patterns of human gamma- and beta-globin promoter DNA methylation.
Blood 2007 Aug 15; 110(4):1343-52
PMID: 17456718 [PubMed - indexed for MEDLINE]

Hsu M, Mabaera R, Lowrey CH, Martin DI, Fiering S
CpG hypomethylation in a large domain encompassing the embryonic beta-like globin genes in primitive erythrocytes.
Mol Cell Biol 2007 Jul; 27(13):5047-54
PMID: 17452448 [PubMed - indexed for MEDLINE]

Ma Y, Fiering S, Black C, Liu X, Yuan Z, Memoli VA, Robbins DJ, Bentley HA, Tsongalis GJ, Demidenko E, Freemantle SJ, Dmitrovsky E
Transgenic cyclin E triggers dysplasia and multiple pulmonary adenocarcinomas.
Proc Natl Acad Sci U S A 2007 Mar 6; 104(10):4089-94
PMID: 17360482 [PubMed - indexed for MEDLINE]

Barre L, Richardson C, Hirshman MF, Brozinick J, Fiering S, Kemp BE, Goodyear LJ, Witters LA
Genetic model for the chronic activation of skeletal muscle AMP-activated protein kinase leads to glycogen accumulation.
Am J Physiol Endocrinol Metab 2007 Mar; 292(3):E802-11
PMID: 17106064 [PubMed - indexed for MEDLINE]

Hu X, Eszterhas S, Pallazzi N, Bouhassira EE, Fields J, Tanabe O, Gerber SA, Bulger M, Engel JD, Groudine M, Fiering S
Transcriptional interference among the murine beta-like globin genes.
Blood 2007 Mar 1; 109(5):2210-6
PMID: 17077320 [PubMed - indexed for MEDLINE]

Hernandez A, Martinez ME, Fiering S, Galton VA, St Germain D
Type 3 deiodinase is critical for the maturation and function of the thyroid axis.
J Clin Invest 2006 Feb; 116(2):476-84
PMID: 16410833 [PubMed - indexed for MEDLINE]

Professional Interests:

Mei Hus, Dr. Fiering, Madu Dharmasena, Patrick Coady, Susan Eszterhas.

My lab investigates the function of various cis-regulatory DNA elements in controlling transcription during mammalian development. Our present focus is on the beta-globin locus and in particular, how expression of one gene at the locus suppresses expression of other nearby genes.

We are also interested in mouse models of cancer and are developing novel mouse models. The influence of tobacco smoke exposure on the innate immune system is another area of research in the lab.

Courses Taught:

Human Genetics graduate course

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