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Surachai Supattapone, M.D., Ph.D.
Title(s):
Assistant Professor of Biochemistry and of Medicine
Department(s):
Biochemistry
Medicine
Education:
Johns Hopkins University School of Medicine, Ph.D. 1992
Johns Hopkins University School of Medicine, M.D. 1992, Oxford University Ph.D. 1991
Programs:
Molecular and Cellular Biology Graduate Programs
Neuroscience Center at Dartmouth
Websites:
http://dms.dartmouth.edu/supattapone/
http://dms.dartmouth.edu/ncd/
Contact Information:
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Dartmouth Medical School HB 7200 Hanover NH 03755 |
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Office: 302 Vail Building Phone: 603-650-1192 Fax: 603-650-1193 Email: supattapone@dartmouth.edu |
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Selected Publications: |
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Supattapone, S., Bouzamondo, E., Ball, H. L., Wille, H., Nguyen, H. O., Cohen, F. E., DeArmond, S. J., Prusiner, S. B., and Scott, M. (2001a). A protease-resistant 61-residue prion peptide causes neurodegeneration in transgenic mice. Molecular and Cellular Biology 21, 2608-16. |
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Professional Interests:
Dr. Supattapone's laboratory is studying the molecular pathogenesis of prion diseases. Prions are unorthodox infectious agents that cause fatal, neurological diseases such as Creutzfeldt Jakob Disease (CJD) in humans and bovine spongiform encephalopathy (BSE) in cows. Unlike other infectious agents, prions do not contain nucleic acids and are comprised instead of a single misfolded protein. The mechanisms by which prions replicate and kill nerve cells remain completely mysterious. This laboratory will use novel approaches, including transgene expression in cultured mammalian cells and invertebrate animals, to investigate these questions.
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