Lab Publications
Journal Articles:
Thompson, S.L., and Compton, D.A.: Examining the link between chromosomal instability and aneuploidy in human cells. J. Cell Biol. 180:665-672 (2008).
Manning, A.L. and Compton, D.A.: Structural and regulatory roles of nonmotor spindle proteins. Curr. Op. Cell Biol. 20:101-106 (2008).
Compton, D.A.: Standing Tall. Dartmouth Medicine 32:70 (2007).
Compton, D.A.: Chromosome orientation. J. Cell Biol. 179:179-181 (2007).
Myers, L.C. and Compton, D.A.: Mitosis: Springtime for chromatin. Curr. Biol. 17:R460-R462 (2007).
Manning, A.L., Ganem, N.J., Bakhoum, S., Wagenbach, M., Wordeman, L., and Compton, D.A.: The kinesin-13 proteins Kif2a, Kif2b and Kif2c/MCAK have distinct roles during mitosis in human cells. Mol. Biol. Cell (2007)
Manning, A.L., and Compton, D.A.: Mechanisms of spindle-pole organization are influenced by kinetochore activity in mammalian cells. Curr. Biol. 17: 260-265 (2007).
Compton, D.A.: Mitosis: Disorderly conduct at kinetochores. Curr. Biol. 16:R494-R496. (2006).
Hall, V.J. Compton, D.A., Stojkovic, P., Nesbitt, M., Herbert, M., Murdoch, A., and Stjkovic, M.: Developmental competience of human in vitro aged oocytes as host cells for nuclear transfer. Hum. Reprod. (2006).
Ganem, N.J, and Compton, D.A.: Functional roles of poleward microtubule flux during mitosis. Cell Cycle 5:481-485. (2006)
Compton, D.A.: Chromosomes walk the line. Nature Cell Biol. 8:308-310. (2006)
Ganem, N.J., Upton, K., and Compton, D.A.: Efficient mitosis in human cells lacking polewards microtubule flux. Curr. Biol. 15:1827-1832 (2005)
Compton, D.A.: Regulation of mitosis by poly(ADP-ribosyl)ation. Biochem. J. 391:e5-e6 (2005)
Compton, D.A.: Mitosis: PARty time in the spindle. Current Biol. 15:R178-179 (2005)
Simerly, C., Navara, C., Hyun, S.H., Lee, B.C., Kang, S.K., Capuano, S., Gosman, G., Dominko, T., Chong, K.-Y., Compton, D., Hwang, W.S., and Schatten, G.: Embryogenesis and blastocyst development after somatic cell nuclear transfer in non-human primates (NHP-SCNT): overcoming defects caused by meiotic spindle extraction. Dev. Biol. 276:237-252 (2004)
Kisurina-Evgenieva, O., Mack, G., Du, Q., Macara, I., Khodjakov, A., and Compton, D.A.: Multiple mechanisms regulate NuMA dynamics at spindle poles. J. Cell Sci. 117:6391-6400 (2004)
Ganem, N., and Compton, D.A.: The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK. J. Cell Biol. 166:473-478 (2004)
Einarson, M.B., Cukierman, E., Compton, D.A., and Glemis, E.A.: Human enhancer of invasion-cluster, a coiled-coil protein required for passage through mitosis. Mol. Cell Biol. 24:3957-3971 (2004)
Chakravarty, A., Howard, L., and Compton, D.A.: A mechanistic model for the organization of microtubule asters by motor and non-motor proteins in a mammalian mitotic extract. Mol. Biol. Cell 15:2116-2132. (2004)
Ota, J., Yamashita, Y., Okawa, K., Kisanuki, H., Fijiwara, S., Ishikawa, M., Choi, Y.L., Ueno, S., Ohki, R., Koinuma, K., Wada, T., Compton, D., Kadoya, T., and Mano, H.: Proteomic analysis of hematopoietic stem cell-like fractions in leukemic disorders. Oncogene 22:5720-5728. (2003)
Levesque, A.A., Howard, L., and Compton, D.A.: A functional relationship between NuMA and Kid is involved in both spindle organization and chromosome alignment in vertebrate cells. Mol. Biol. Cell 14:3541-3552. (2003)
Simerly, C., Dominko, T., Navara, C., Payne, C., Capuano, S., Gosman, G., Chong, K.-Y., Takahashi, D., Chace, C., Compton, D., Hewitson, L., and Schatten, G.: Molecular correlates of primate nuclear transfer failures. Science 300: 297 (2003).
Khodjakov, A., Copenagle, L., Gordon, M.B., Compton, D.A., and Kapoor, T.M.: Minus-end capture of preformed kinetochore fibers contributes to spindle morphogenesis J. Cell Biol. 160:671-683 (2003).
Garrett, S., Auer, K., Compton, D.A., and Kapoor, T.M.: hTPX2 is required for normal spindle morphology and centrosome integrity during vertebrate cell division.Curr. Biol. 12:2055-2059 (2002).
Du, Q., Taylor, L., Compton, D.A., and Macara I.G.: LGN blocks the ability of NuMA to bind and stabilize microtubules: a mechanism for mitotic spindle assembly regulation.Curr. Biol. 12:1928-1933 (2002).
Compton, D.A.: Chromosome Segregation: Pulling from the Poles. Curr. Biol. 12:R651-R653 (2002).
Kapoor,T.M. and Compton, D.A.: Searching for the middle ground: mechanisms of chromosome alignment during mitosis. J. Cell Biol. 157:551-556. (2002).
Mack, G. and Compton, D.A.: Analysis of mitotic microtubule-associated proteins using mass spectrometry identifies astrin, a novel spindle-associated protein. Proc. Natl. Acad. Sci., USA. 98:14434-14439.(2001).
Levesque, A. and Compton, D.A.: The chromokinesin Kid is necessary for chromosome arm orientation and oscillation, but not congression, on mitotic spindles. J. Cell Biol. 154:1135-1146. (2001).
Gordon, M., Howard, L., and Compton, D.A.: Chromosome movement in mitosis requires microtubule anchorage at spindle poles. J. Cell Biol. 152:425-434. (2001).
Dionne, M.A., Sanchez, A., and Compton, D.A.: ch-TOGp is required for microtubule aster formation in a mammalian mitotic extract. J. Biol. Chem. 275:12346-12352. (2000).
Ye, K., Compton, D.A., Lai, M.M., Walensky, L.D., and Snyder, S.H.: Protein 4.1N binding to nuclear NuMA in PC12 cells mediates the anti-proliferative actions of nerve growth factor. J. Neuroscience 19:10747-10756 (1999).
Mountain, V., Simerly, C., Howard, L., Ando, A., Schatten, G., and Compton, D.A.: The kinesin-related protein HSET opposes the activity of Eg5 and cross links microtubules in the mammalian mitotic spindle. J. Cell Biol. 147:351-365. (1999).
Quintyne, N.J., Gill, S.R., Eckley, D.M., Crego, C.L., Compton, D.A., and Schroer, T.A.: Dynactin is required for microtubule anchoring at centrosomes. J. Cell Biol. 147:321-334 (1999).
Dionne, M.A., Howard, L., and Compton, D.A.: NuMA is a component of an insoluble matrix at mitotic spindle poles. Cell Motil. Cytoskel. 42:189-203. (1999).
Compton, D.A.: Focusing on spindle poles. J. Cell Sci. 111:1477-1481 (1998).
Gaglio, T., Dionne, M.A., and Compton, D.A.: Mitotic spindle poles are organized by structural and motor proteins in addition to centrosomes. J. Cell Biol. 138:1055-1066 (1997).
Saredi, A., Howard, L., and Compton, D.A.: Phosphorylation regulates the assembly of NuMA in a mammalian mitotic extract. J. Cell Sci. 110:1287-1297 (1997).
Gaglio, T., Saredi, A., Bingham, J.B., Hasbani, M.J., Gill, S.R., Schroer, T.A., and Compton, D.A.: Opposing motor activities are required for the organization of the polar ends of the mammalian mitotic spindle. J. Cell Biol. 135:399-414 (1996).
Saredi, A., Howard, L., and Compton, D.A.: NuMA assembles into an extensive filamentous structure when expressed in the cell cytoplasm. J. Cell Sci. 109:619-630 (1996).
Gaglio, T., Saredi, A., and Compton, D.A.: NuMA is required for the organization of microtubules into aster-like mitotic arrays. J. Cell Biol. 131:693-708 (1995).
Compton, D.A., and Luo, C.: Mutation of the predicted p34cdc2 phosphorylation sites in NuMA impair the assembly of the mitotic spindle and block mitosis. J. Cell Sci. 108:621-633 (1995).
Invited Book Chapters:
Compton, D.A.: In vitro approaches for the study of molecular motors in aster formation. Methods in Cell Biol. 67:225-239. (2001).
Compton, D.A.: Spindle assembly in animal cells. Ann. Rev. Biochem.. 69:95-114 (2000).
Mountain, V., and Compton, D.A.: Dissecting the role of molecular motors in the mitotic spindle. Anat. Rec. (New Anat), 261:14-24 (2000).
Compton, D.A.: New tools for the anti-mitotic toolbox. Science 286:913-914 (1999).
Gueth-Hallonet, C., Osborn, M., and Compton, D.A.: NuMA. in Guidebook to the Cytoskeletal and Motor Proteins; ed. Ron Vale and Thomas Kreis; Oxford University Press, Oxford, UK (1997).
Compton, D.A.: Production of M-phase and I-phase extracts from mammalian cells. in Molecular Motors and the Cytoskeleton: Part B (a volume of Methods in Enzymology); ed. Richard B. Vallee; Academic Press, San Diego, CA. (1997).